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Am. J. Trop. Med. Hyg., 58(6), 1998, pp. 763-767
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 58, Issue 6, 763-767
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


A target for intervention in Plasmodium falciparum infections

FE McKenzie and WH Bossert

We present a set of simple mathematical models to investigate interactions between malaria parasites and the human immune system and the differentiation of parasites from asexual, pathogenic into sexual, transmissible blood stages. Each model represents a different combination of empirically based hypotheses, and salient behaviors of each fit criteria developed from clinical data. In all models, however, higher gametocyte conversion rates result in lower peak asexual-form densities. Therefore, to the extent that asexual-form densities are associated with disease symptoms, interventions that stimulate gametocytogenesis should produce unexpected clinical benefits.


This article has been cited by other articles:


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 Am J Trop Med HygHome page
P. G. MCQUEEN and F. E. MCKENZIE
Competition for red blood cells can enhance Plasmodium vivax parasitemia in mixed-species malaria infections.
Am J Trop Med Hyg, July 1, 2006; 75(1): 112 - 125.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
P. G. McQueen and F. E. McKenzie
Age-structured red blood cell susceptibility and the dynamics of malaria infections
PNAS, June 15, 2004; 101(24): 9161 - 9166.
[Abstract] [Full Text] [PDF]


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Copyright © 1998 by the American Society of Tropical Medicine and Hygiene.