Research Articles

Surveillance for Ross River virus infection using blood donors

The number of clinical Ross River virus (RRV) infections (epidemic polyarthritis) each year in Australia continues to grow despite extensive vector control programs. There is a need, therefore, for a surveillance program that can give sufficient warning of outbreaks of the disease so that highly focused preventative measures may be undertaken. The ability of a surveillance program, based on voluntary Red Cross blood donations, to predict outbreaks of epidemic polyarthritis was evaluated. Anti-RRV IgM antibody was detected in significant numbers of blood donors from throughout the state of Queensland 6-9 weeks prior to an increase in the number of notified cases of epidemic polyarthritis. At a local level, significant numbers of anti-RRV IgM blood donors were detected in Brisbane in 1996 four weeks prior to an increase in the number of notified cases of epidemic polyarthritis. This system of surveillance is technically simple, rapid (results are obtained in 2-3 days), it samples the human population from throughout the state, and it gives timely warning of outbreaks of epidemic polyarthritis.

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				D. Harley, A. Sleigh, and S. Ritchie Ross River Virus Transmission, Infection, and Disease: a Cross-Disciplinary Review Clin. Microbiol. Rev., October 1, 2001; 14(4): 909 - 932. [Abstract] [Full Text] [PDF]