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Am. J. Trop. Med. Hyg., 58(4), 1998, pp. 424-430
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 58, Issue 4, 424-430
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: measurement of local host responses

L Franco, L Najvar, BL Gomez, S Restrepo, Graybill JR, and A Restrepo

Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-alpha and transforming growth factor-beta. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.


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B. L. Gomez, J. D. Nosanchuk, S. Diez, S. Youngchim, P. Aisen, L. E. Cano, A. Restrepo, A. Casadevall, and A. J. Hamilton
Detection of Melanin-Like Pigments in the Dimorphic Fungal Pathogen Paracoccidioides brasiliensis In Vitro and during Infection
Infect. Immun., September 1, 2001; 69(9): 5760 - 5767.
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R. Bialek, A. Ibricevic, C. Aepinus, L. K. Najvar, A. W. Fothergill, J. Knobloch, and J. R. Graybill
Detection of Paracoccidioides brasiliensis in Tissue Samples by a Nested PCR Assay
J. Clin. Microbiol., August 1, 2000; 38(8): 2940 - 2942.
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Copyright © 1998 by the American Society of Tropical Medicine and Hygiene.