AJTMH Tropical Medicine and Hygiene News
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 58(4), 1998, pp. 406-413
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taylor, R.
Right arrow Articles by Riley, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taylor, R.
Right arrow Articles by Riley, E.
Related Collections
Right arrow Malaria
Right arrow Plasmodium
American Journal of Tropical Medicine and Hygiene, Vol 58, Issue 4, 406-413
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


IgG3 antibodies to Plasmodium falciparum merozoite surface protein 2 (MSP2): increasing prevalence with age and association with clinical immunity to malaria

RR Taylor, SJ Allen, BM Greenwood, and EM Riley

In a cross-sectional survey carried out in west Africa (The Gambia), where Plasmodium falciparum malaria is endemic with seasonal transmission, 178 individuals 1-75 years of age were assessed for their antibody response to the malaria vaccine candidate, merozoite surface protein 2 (MSP2). Total IgG to recombinant antigens representing full-length, repetitive, and group-specific domains of both allelic families of MSP2 was determined by ELISA. The IgG-subclass profile of IgG-positive sera was assessed. Antibody prevalence was age-dependent, reaching a peak during adolescence. In MSP2-seropositive individuals, there was a predominance of cytophilic antibodies (IgG1 and IgG3); IgG1 antibodies were prevalent in children less than 10 years of age, whereas in adolescents and adults MSP2-specific antibodies were predominantly IgG3. In parallel, we conducted a longitudinal study of children (3-8 years of age) from the same community; sera collected before the malaria transmission season were tested for the presence of anti-MSP2 antibodies. The subsequent susceptibility of these children to clinical malaria was monitored and the association between anti-MSP2 antibodies of different IgG subclasses and resistance to clinical malaria was tested. The presence of IgG3 antibodies to MSP2 serogroup A was negatively associated with the risk of clinical malaria whereas IgG1 antibodies to MSP2 serogroup B were associated with an increased risk of clinical infection. Our data suggest that age/exposure-related acquisition of IgG3 antibodies to MSP2 may contribute to the development of clinically protective immunity to malaria.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
D. I. Stanisic, J. S. Richards, F. J. McCallum, P. Michon, C. L. King, S. Schoepflin, P. R. Gilson, V. J. Murphy, R. F. Anders, I. Mueller, et al.
Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparum Merozoite Antigens Are Associated with Control of Parasitemia and Protection from Symptomatic Illness
Infect. Immun., March 1, 2009; 77(3): 1165 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. S. Noland, B. Hendel-Paterson, X. M. Min, A. M. Moormann, J. M. Vulule, D. L. Narum, D. E. Lanar, J. W. Kazura, and C. C. John
Low Prevalence of Antibodies to Preerythrocytic but Not Blood-Stage Plasmodium falciparum Antigens in an Area of Unstable Malaria Transmission Compared to Prevalence in an Area of Stable Malaria Transmission
Infect. Immun., December 1, 2008; 76(12): 5721 - 5728.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
F. H. A. Osier, G. Fegan, S. D. Polley, L. Murungi, F. Verra, K. K. A. Tetteh, B. Lowe, T. Mwangi, P. C. Bull, A. W. Thomas, et al.
Breadth and Magnitude of Antibody Responses to Multiple Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Clinical Malaria
Infect. Immun., May 1, 2008; 76(5): 2240 - 2248.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
O. J. Akpogheneta, N. O. Duah, K. K. A. Tetteh, S. Dunyo, D. E. Lanar, M. Pinder, and D. J. Conway
Duration of Naturally Acquired Antibody Responses to Blood-Stage Plasmodium falciparum Is Age Dependent and Antigen Specific
Infect. Immun., April 1, 2008; 76(4): 1748 - 1755.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. C. Gray, P. H. Corran, E. Mangia, M. W. Gaunt, Q. Li, K. K.A. Tetteh, S. D. Polley, D. J. Conway, A. A. Holder, T. Bacarese-Hamilton, et al.
Profiling the Antibody Immune Response against Blood Stage Malaria Vaccine Candidates
Clin. Chem., July 1, 2007; 53(7): 1244 - 1253.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
K. K. G. SCOPEL, M. D. SILVA-NUNES, R. S. MALAFRONTE, E. M. BRAGA, and M. U. FERREIRA
VARIANT-SPECIFIC ANTIBODIES TO MEROZOITE SURFACE PROTEIN 2 AND CLINICAL EXPRESSION OF PLASMODIUM FALCIPARUM MALARIA IN RURAL AMAZONIANS
Am J Trop Med Hyg, June 1, 2007; 76(6): 1084 - 1091.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
D. J. Conway
Molecular Epidemiology of Malaria
Clin. Microbiol. Rev., January 1, 2007; 20(1): 188 - 204.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
K. K. G. Scopel, C. J. F. Fontes, M. U. Ferreira, and E. M. Braga
Factors Associated with Immunoglobulin G Subclass Polarization in Naturally Acquired Antibodies to Plasmodium falciparum Merozoite Surface Proteins: a Cross-Sectional Survey in Brazilian Amazonia.
Clin. Vaccine Immunol., July 1, 2006; 13(7): 810 - 813.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. Lundquist, L. K. Nielsen, A. Jafarshad, D. SoeSoe, L. H. Christensen, P. Druilhe, and M. H. Dziegiel
Human Recombinant Antibodies against Plasmodium falciparum Merozoite Surface Protein 3 Cloned from Peripheral Blood Leukocytes of Individuals with Immunity to Malaria Demonstrate Antiparasitic Properties.
Infect. Immun., June 1, 2006; 74(6): 3222 - 3231.
[Abstract] [Full Text] [PDF]

Home page
 Clin Med ResHome page
F. S. Toure, P. Deloron, and F. Migot-Nabias
Analysis of Human Antibodies to Erythrocyte Binding Antigen 175 Peptide 4 of Plasmodium falciparum.
Clin. Med. Res., March 1, 2006; 4(1): 1 - 6.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. E. Tongren, C. J. Drakeley, S. L. R. McDonald, H. G. Reyburn, A. Manjurano, W. M. M. Nkya, M. M. Lemnge, C. D. Gowda, J. E. Todd, P. H. Corran, et al.
Target Antigen, Age, and Duration of Antigen Exposure Independently Regulate Immunoglobulin G Subclass Switching in Malaria
Infect. Immun., January 1, 2006; 74(1): 257 - 264.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. E. Tongren, P. H. Corran, W. Jarra, J. Langhorne, and E. M. Riley
Epitope-Specific Regulation of Immunoglobulin Class Switching in Mice Immunized with Malarial Merozoite Surface Proteins
Infect. Immun., December 1, 2005; 73(12): 8119 - 8129.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. K. A. Tetteh, D. R. Cavanagh, P. Corran, R. Musonda, J. S. McBride, and D. J. Conway
Extensive Antigenic Polymorphism within the Repeat Sequence of the Plasmodium falciparum Merozoite Surface Protein 1 Block 2 Is Incorporated in a Minimal Polyvalent Immunogen
Infect. Immun., September 1, 2005; 73(9): 5928 - 5935.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
T. M. TRAN, J. OLIVEIRA-FERREIRA, A. MORENO, F. SANTOS, S. S. YAZDANI, C. E. CHITNIS, J. D. ALTMAN, E. V-S. MEYER, J. W. BARNWELL, and M. R. GALINSKI
COMPARISON OF IgG REACTIVITIES TO PLASMODIUM VIVAX MEROZOITE INVASION ANTIGENS IN A BRAZILIAN AMAZON POPULATION
Am J Trop Med Hyg, August 1, 2005; 73(2): 244 - 255.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. L. R. P. Yone, P. G. Kremsner, and A. J. F. Luty
Immunoglobulin G Isotype Responses to Erythrocyte Surface-Expressed Variant Antigens of Plasmodium falciparum Predict Protection from Malaria in African Children
Infect. Immun., April 1, 2005; 73(4): 2281 - 2287.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
M. U. Ferreira, M. da Silva Nunes, and G. Wunderlich
Antigenic Diversity and Immune Evasion by Malaria Parasites
Clin. Vaccine Immunol., November 1, 2004; 11(6): 987 - 995.
[Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. H. Johnson, R. G. F. Leke, N. R. Mendell, D. Shon, Y. J. Suh, D. Bomba-Nkolo, V. Tchinda, S. Kouontchou, L. W. Thuita, A. M. van der Wel, et al.
Human Leukocyte Antigen Class II Alleles Influence Levels of Antibodies to the Plasmodium falciparum Asexual-Stage Apical Membrane Antigen 1 but Not to Merozoite Surface Antigen 2 and Merozoite Surface Protein 1
Infect. Immun., May 1, 2004; 72(5): 2762 - 2771.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Soe, M. Theisen, C. Roussilhon, K.-S. Aye, and P. Druilhe
Association between Protection against Clinical Malaria and Antibodies to Merozoite Surface Antigens in an Area of Hyperendemicity in Myanmar: Complementarity between Responses to Merozoite Surface Protein 3 and the 220-Kilodalton Glutamate-Rich Protein
Infect. Immun., January 1, 2004; 72(1): 247 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
G. S. COOKE, C. AUCAN, A. J. WALLEY, S. SEGAL, B. M. GREENWOOD, D. P. KWIATKOWSKI, and A. V. S. HILL
ASSOCIATION OF Fc{gamma} RECEPTOR IIa (CD32) POLYMORPHISM WITH SEVERE MALARIA IN WEST AFRICA
Am J Trop Med Hyg, December 1, 2003; 69(6): 565 - 568.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
K. A. Kanunfre, F. M. S. Leoratti, E. H. E. Hoffmann, R. R. Durlacher, A. W. Ferreira, S. L. Moraes-Avila, and M. U. Ferreira
Differential Recognition of Plasmodium falciparum Merozoite Surface Protein 2 Variants by Antibodies from Malaria Patients in Brazil
Clin. Vaccine Immunol., September 1, 2003; 10(5): 973 - 976.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Franks, L. Baton, K. Tetteh, E. Tongren, D. Dewin, B. D. Akanmori, K. A. Koram, L. Ranford-Cartwright, and E. M. Riley
Genetic Diversity and Antigenic Polymorphism in Plasmodium falciparum: Extensive Serological Cross-Reactivity between Allelic Variants of Merozoite Surface Protein 2
Infect. Immun., June 1, 2003; 71(6): 3485 - 3495.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
O. Garraud, R. Perraut, A. Diouf, W. S. Nambei, A. Tall, A. Spiegel, S. Longacre, D. C. Kaslow, H. Jouin, D. Mattei, et al.
Regulation of Antigen-Specific Immunoglobulin G Subclasses in Response to Conserved and Polymorphic Plasmodium falciparum Antigens in an In Vitro Model
Infect. Immun., June 1, 2002; 70(6): 2820 - 2827.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Theisen, D. Dodoo, A. Toure-Balde, S. Soe, G. Corradin, K. K. Koram, J. A. L. Kurtzhals, L. Hviid, T. Theander, B. Akanmori, et al.
Selection of Glutamate-Rich Protein Long Synthetic Peptides for Vaccine Development: Antigenicity and Relationship with Clinical Protection and Immunogenicity
Infect. Immun., September 1, 2001; 69(9): 5223 - 5229.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. Wang, T. L. Richie, A. Stowers, D. H. Nhan, and R. L. Coppel
Naturally Acquired Antibody Responses to Plasmodium falciparum Merozoite Surface Protein 4 in a Population Living in an Area of Endemicity in Vietnam
Infect. Immun., July 1, 2001; 69(7): 4390 - 4397.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Weisman, L. Wang, H. Billman-Jacobe, D. H. Nhan, T. L. Richie, and R. L. Coppel
Antibody Responses to Infections with Strains of Plasmodium falciparum Expressing Diverse Forms of Merozoite Surface Protein 2
Infect. Immun., February 1, 2001; 69(2): 959 - 967.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. Aucan, Y. Traore, F. Fumoux, and P. Rihet
Familial Correlation of Immunoglobulin G Subclass Responses to Plasmodium falciparum Antigens in Burkina Faso
Infect. Immun., February 1, 2001; 69(2): 996 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. M. N. Okenu, E. M. Riley, Q. D. Bickle, P. U. Agomo, A. Barbosa, J. R. Daugherty, D. E. Lanar, and D. J. Conway
Analysis of Human Antibodies to Erythrocyte Binding Antigen 175 of Plasmodium falciparum
Infect. Immun., October 1, 2000; 68(10): 5559 - 5566.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. M. Riley, G. E. Wagner, M. F. Ofori, J. G. Wheeler, B. D. Akanmori, K. Tetteh, D. McGuinness, S. Bennett, F. K. Nkrumah, R. F. Anders, et al.
Lack of Association between Maternal Antibody and Protection of African Infants from Malaria Infection
Infect. Immun., October 1, 2000; 68(10): 5856 - 5863.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. Aucan, Y. Traore, F. Tall, B. Nacro, T. Traore-Leroux, F. Fumoux, and P. Rihet
High Immunoglobulin G2 (IgG2) and Low IgG4 Levels Are Associated with Human Resistance to Plasmodium falciparum Malaria
Infect. Immun., March 1, 2000; 68(3): 1252 - 1258.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
M. H. Shearer, R. D. Dark, J. Chodosh, and R. C. Kennedy
Comparison and Characterization of Immunoglobulin G Subclasses among Primate Species
Clin. Vaccine Immunol., November 1, 1999; 6(6): 953 - 958.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Society of Tropical Medicine and Hygiene.