AJTMH Tropical Medicine and Hygiene News
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 58(2), 1998, pp. 211-219
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Branch, O.
Right arrow Articles by Lal, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Branch, O.
Right arrow Articles by Lal, A.
Related Collections
Right arrow Epidemiology
Right arrow Malaria
Right arrow Plasmodium
American Journal of Tropical Medicine and Hygiene, Vol 58, Issue 2, 211-219
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


A longitudinal investigation of IgG and IgM antibody responses to the merozoite surface protein-1 19-kiloDalton domain of Plasmodium falciparum in pregnant women and infants: associations with febrile illness, parasitemia, and anemia

OH Branch, V Udhayakumar, AW Hightower, AJ Oloo, WA Hawley, BL Nahlen, PB Bloland, DC Kaslow, and AA Lal

This study was aimed at delineating characteristics of naturally acquired immunity against the merozoite surface antigen-1 (MSP-1) of Plasmodium falciparum, a candidate malaria vaccine antigen. A case/control study was performed on 75 case/control pairs of infants with febrile illness at the time of the first detected infection indicating a clinical case. The presence and level of antibodies at one month prior to the first infection and at the time of the first infection in the afebrile group was significantly higher than in the febrile group. Decreased parasite density and decreased infection-related loss of hemoglobin was seen in infants with anti-MSP-1(19kD) IgG antibodies. In addition, mothers who were positive for the presence of these antibodies conferred protection against placental infection and infection in their infants. In this study, development of anti-MSP-1(19kD) antibody responses in 24 infants were studied longitudinally using monthly serum samples collected from birth until approximately one year of age. In addition, umbilical cord blood sera and respective mothers' sera were analyzed. Longitudinal studies of antibody responses revealed several short-lived IgG and IgM peaks throughout an infant's first year that correlated with detection of parasitemia. The protection against parasitemia and febrile illness was observed in infants when anti-MSP-1(19kD) antibodies were present; when infants were negative for IgG, they had a 10-times greater risk of becoming parasitemic. These data from a longitudinal and prospective study of malaria suggest a protective role for anti-MSP-1(19kD) antibodies in infants and pregnant women.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
P. Bejon, G. Warimwe, C. L. Mackintosh, M. J. Mackinnon, S. M. Kinyanjui, J. N. Musyoki, P. C. Bull, and K. Marsh
Analysis of Immunity to Febrile Malaria in Children That Distinguishes Immunity from Lack of Exposure
Infect. Immun., May 1, 2009; 77(5): 1917 - 1923.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. I. Stanisic, J. S. Richards, F. J. McCallum, P. Michon, C. L. King, S. Schoepflin, P. R. Gilson, V. J. Murphy, R. F. Anders, I. Mueller, et al.
Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparum Merozoite Antigens Are Associated with Control of Parasitemia and Protection from Symptomatic Illness
Infect. Immun., March 1, 2009; 77(3): 1165 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. S. Noland, B. Hendel-Paterson, X. M. Min, A. M. Moormann, J. M. Vulule, D. L. Narum, D. E. Lanar, J. W. Kazura, and C. C. John
Low Prevalence of Antibodies to Preerythrocytic but Not Blood-Stage Plasmodium falciparum Antigens in an Area of Unstable Malaria Transmission Compared to Prevalence in an Area of Stable Malaria Transmission
Infect. Immun., December 1, 2008; 76(12): 5721 - 5728.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
F. H. A. Osier, G. Fegan, S. D. Polley, L. Murungi, F. Verra, K. K. A. Tetteh, B. Lowe, T. Mwangi, P. C. Bull, A. W. Thomas, et al.
Breadth and Magnitude of Antibody Responses to Multiple Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Clinical Malaria
Infect. Immun., May 1, 2008; 76(5): 2240 - 2248.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
O. J. Akpogheneta, N. O. Duah, K. K. A. Tetteh, S. Dunyo, D. E. Lanar, M. Pinder, and D. J. Conway
Duration of Naturally Acquired Antibody Responses to Blood-Stage Plasmodium falciparum Is Age Dependent and Antigen Specific
Infect. Immun., April 1, 2008; 76(4): 1748 - 1755.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
I. Nebie, A. Diarra, A. Ouedraogo, I. Soulama, E. C. Bougouma, A. B. Tiono, A. T. Konate, R. Chilengi, M. Theisen, D. Dodoo, et al.
Humoral Responses to Plasmodium falciparum Blood-Stage Antigens and Association with Incidence of Clinical Malaria in Children Living in an Area of Seasonal Malaria Transmission in Burkina Faso, West Africa
Infect. Immun., February 1, 2008; 76(2): 759 - 766.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. J. Rogerson, V. Mwapasa, and S. R. Meshnick
Malaria in Pregnancy: Linking Immunity and Pathogenesis to Prevention
Am J Trop Med Hyg, December 1, 2007; 77(6_Suppl): 14 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
A. E. Dent, C. T. Yohn, P. A. Zimmerman, J. Vulule, J. W. Kazura, and A. M. Moormann
A Polymerase Chain Reaction/Ligase Detection Reaction Fluorescent Microsphere Assay to Determine Plasmodium falciparum MSP-119 Haplotypes
Am J Trop Med Hyg, August 1, 2007; 77(2): 250 - 255.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. L. TAKALA, D. L. SMITH, M. A. THERA, D. COULIBALY, O. K. DOUMBO, and C. V. PLOWE
RARE PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN 1 19-KDA (MSP-119) HAPLOTYPES IDENTIFIED IN MALI USING HIGH-THROUGHPUT GENOTYPING METHODS
Am J Trop Med Hyg, May 1, 2007; 76(5): 855 - 859.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Dent, I. Malhotra, P. Mungai, E. Muchiri, B. S. Crabb, J. W. Kazura, and C. L. King
Prenatal Malaria Immune Experience Affects Acquisition of Plasmodium falciparum Merozoite Surface Protein-1 Invasion Inhibitory Antibodies during Infancy
J. Immunol., November 15, 2006; 177(10): 7139 - 7145.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. P. A. Lusingu, A. T. R. Jensen, L. S. Vestergaard, D. T. Minja, M. B. Dalgaard, S. Gesase, B. P. Mmbando, A. Y. Kitua, M. M. Lemnge, D. Cavanagh, et al.
Levels of Plasma Immunoglobulin G with Specificity against the Cysteine-Rich Interdomain Regions of a Semiconserved Plasmodium falciparum Erythrocyte Membrane Protein 1, VAR4, Predict Protection against Malarial Anemia and Febrile Episodes.
Infect. Immun., May 1, 2006; 74(5): 2867 - 2875.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Pinder, C. J. Sutherland, F. Sisay-Joof, J. Ismaili, M. B. B. McCall, R. Ord, R. Hallett, A. A. Holder, and P. Milligan
Immunoglobulin G Antibodies to Merozoite Surface Antigens Are Associated with Recovery from Chloroquine-Resistant Plasmodium falciparum in Gambian Children.
Infect. Immun., May 1, 2006; 74(5): 2887 - 2893.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
C. C. JOHN, A. M. MOORMANN, D. C. PREGIBON, P. O. SUMBA, M. M. MCHUGH, D. L. NARUM, D. E. LANAR, M. D. SCHLUCHTER, and J. W. KAZURA
CORRELATION OF HIGH LEVELS OF ANTIBODIES TO MULTIPLE PRE-ERYTHROCYTIC PLASMODIUM FALCIPARUM ANTIGENS AND PROTECTION FROM INFECTION
Am J Trop Med Hyg, July 1, 2005; 73(1): 222 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
I. Malhotra, P. Mungai, E. Muchiri, J. Ouma, S. Sharma, J. W. Kazura, and C. L. King
Distinct Th1- and Th2-Type Prenatal Cytokine Responses to Plasmodium falciparum Erythrocyte Invasion Ligands
Infect. Immun., June 1, 2005; 73(6): 3462 - 3470.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. R. Elliott, R. D. Kuns, and M. F. Good
Heterologous Immunity in the Absence of Variant-Specific Antibodies after Exposure to Subpatent Infection with Blood-Stage Malaria
Infect. Immun., April 1, 2005; 73(4): 2478 - 2485.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
P. C. Bonner, Z. Zhou, L. B. Mirel, J. G. Ayisi, Y. P. Shi, A. M. van Eijk, J. A. Otieno, B. L. Nahlen, R. W. Steketee, and V. Udhayakumar
Placental Malaria Diminishes Development of Antibody Responses to Plasmodium falciparum Epitopes in Infants Residing in an Area of Western Kenya Where P. falciparum Is Endemic
Clin. Vaccine Immunol., March 1, 2005; 12(3): 375 - 379.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. R. Cavanagh, D. Dodoo, L. Hviid, J. A. L. Kurtzhals, T. G. Theander, B. D. Akanmori, S. Polley, D. J. Conway, K. Koram, and J. S. McBride
Antibodies to the N-Terminal Block 2 of Plasmodium falciparum Merozoite Surface Protein 1 Are Associated with Protection against Clinical Malaria
Infect. Immun., November 1, 2004; 72(11): 6492 - 6502.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. L. Gatton and Q. Cheng
Modeling the Development of Acquired Clinical Immunity to Plasmodium falciparum Malaria
Infect. Immun., November 1, 2004; 72(11): 6538 - 6545.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. C. John, R. A. O'Donnell, P. O. Sumba, A. M. Moormann, T. F. de Koning-Ward, C. L. King, J. W. Kazura, and B. S. Crabb
Evidence That Invasion-Inhibitory Antibodies Specific for the 19-kDa Fragment of Merozoite Surface Protein-1 (MSP-119) Can Play a Protective Role against Blood-Stage Plasmodium falciparum Infection in Individuals in a Malaria Endemic Area of Africa
J. Immunol., July 1, 2004; 173(1): 666 - 672.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. H. Johnson, R. G. F. Leke, N. R. Mendell, D. Shon, Y. J. Suh, D. Bomba-Nkolo, V. Tchinda, S. Kouontchou, L. W. Thuita, A. M. van der Wel, et al.
Human Leukocyte Antigen Class II Alleles Influence Levels of Antibodies to the Plasmodium falciparum Asexual-Stage Apical Membrane Antigen 1 but Not to Merozoite Surface Antigen 2 and Merozoite Surface Protein 1
Infect. Immun., May 1, 2004; 72(5): 2762 - 2771.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. I. Stanisic, L. B. Martin, M. L. Gatton, and M. F. Good
Inhibition of 19-kDa C-Terminal Region of Merozoite Surface Protein-1-Specific Antibody Responses in Neonatal Pups by Maternally Derived 19-kDa C-Terminal Region of Merozoite Surface Protein-1-Specific Antibodies but Not Whole Parasite-Specific Antibodies
J. Immunol., May 1, 2004; 172(9): 5570 - 5581.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. A. Okech, P. H. Corran, J. Todd, A. Joynson-Hicks, C. Uthaipibull, T. G. Egwang, A. A. Holder, and E. M. Riley
Fine Specificity of Serum Antibodies to Plasmodium falciparum Merozoite Surface Protein, PfMSP-119, Predicts Protection from Malaria Infection and High-Density Parasitemia
Infect. Immun., March 1, 2004; 72(3): 1557 - 1567.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. W. Taylor, A. Zhou, L. E. Marsillio, L. W. Thuita, E. B. Leke, O. Branch, D. C. Gowda, C. Long, and R. F. G. Leke
Antibodies That Inhibit Binding of Plasmodium falciparum-Infected Erythrocytes to Chondroitin Sulfate A and to the C Terminus of Merozoite Surface Protein 1 Correlate with Reduced Placental Malaria in Cameroonian Women
Infect. Immun., March 1, 2004; 72(3): 1603 - 1607.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. I. Stanisic, L. B. Martin, and M. F. Good
The Role of the 19-kDa Region of Merozoite Surface Protein 1 and Whole-Parasite-Specific Maternal Antibodies in Directing Neonatal Pups' Responses to Rodent Malaria Infection
J. Immunol., November 15, 2003; 171(10): 5461 - 5469.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. D. Polley, K. K. A. Tetteh, D. R. Cavanagh, R. J. Pearce, J. M. Lloyd, K. A. Bojang, D. M. N. Okenu, B. M. Greenwood, J. S. McBride, and D. J. Conway
Repeat Sequences in Block 2 of Plasmodium falciparum Merozoite Surface Protein 1 Are Targets of Antibodies Associated with Protection from Malaria
Infect. Immun., April 1, 2003; 71(4): 1833 - 1842.
[Abstract] [Full Text]

Home page
 Am J Trop Med HygHome page
S. K. KARIUKI, F. O. TER KUILE, K. WANNEMUEHLER, D. J. TERLOUW, M. S. KOLCZAK, W. A. HAWLEY, P. A. PHILLIPS-HOWARD, A. S. S. ORAGO, B. L. NAHLEN, A. A. LAL, et al.
EFFECTS OF PERMETHRIN-TREATED BED NETS ON IMMUNITY TO MALARIA IN WESTERN KENYA I. ANTIBODY RESPONSES IN PREGNANT WOMEN AND CORD BLOOD IN AN AREA OF INTENSE MALARIA TRANSMISSION
Am J Trop Med Hyg, April 1, 2003; 68(90040): 61 - 67.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. K. KARIUKI, A. A. LAL, D. J. TERLOUW, F. O. TER KUILE, J. M. O. ONG'ECHA, P. A. PHILLIPS-HOWARD, A. S. S. ORAGO, M. S. KOLCZAK, W. A. HAWLEY, B. L. NAHLEN, et al.
EFFECTS OF PERMETHRIN-TREATED BED NETS ON IMMUNITY TO MALARIA IN WESTERN KENYA II. ANTIBODY RESPONSES IN YOUNG CHILDREN IN AN AREA OF INTENSE MALARIA TRANSMISSION
Am J Trop Med Hyg, April 1, 2003; 68(90040): 108 - 114.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. L. King, I. Malhotra, A. Wamachi, J. Kioko, P. Mungai, S. A. Wahab, D. Koech, P. Zimmerman, J. Ouma, and J. W. Kazura
Acquired Immune Responses to Plasmodium falciparum Merozoite Surface Protein-1 in the Human Fetus
J. Immunol., January 1, 2002; 168(1): 356 - 364.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
O. H. Branch, S. Takala, S. Kariuki, B. L. Nahlen, M. Kolczak, W. Hawley, and A. A. Lal
Plasmodium falciparum Genotypes, Low Complexity of Infection, and Resistance to Subsequent Malaria in Participants in the Asembo Bay Cohort Project
Infect. Immun., December 1, 2001; 69(12): 7783 - 7792.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
R. A. O'Donnell, T. F. de Koning-Ward, R. A. Burt, M. Bockarie, J. C. Reeder, A. F. Cowman, and B. S. Crabb
Antibodies Against Merozoite Surface Protein (MSP)-119 Are a Major Component of the Invasion-inhibitory Response in Individuals Immune to Malaria
J. Exp. Med., June 18, 2001; 193(12): 1403 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
R. S. Naik, O. H. Branch, A. S. Woods, M. Vijaykumar, D. J. Perkins, B. L. Nahlen, A. A. Lal, R. J. Cotter, C. E. Costello, C. F. Ockenhouse, et al.
Glycosylphosphatidylinositol Anchors of Plasmodium falciparum: Molecular Characterization and Naturally Elicited Antibody Response That May Provide Immunity to Malaria Pathogenesis
J. Exp. Med., November 27, 2000; 192(11): 1563 - 1576.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. M. Riley, G. E. Wagner, M. F. Ofori, J. G. Wheeler, B. D. Akanmori, K. Tetteh, D. McGuinness, S. Bennett, F. K. Nkrumah, R. F. Anders, et al.
Lack of Association between Maternal Antibody and Protection of African Infants from Malaria Infection
Infect. Immun., October 1, 2000; 68(10): 5856 - 5863.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. A. Da Silveira, M. L. Dorta, E. A. S. Kimura, A. M. Katzin, F. Kawamoto, K. Tanabe, and M. U. Ferreira
Allelic Diversity and Antibody Recognition of Plasmodium falciparum Merozoite Surface Protein 1 during Hypoendemic Malaria Transmission in the Brazilian Amazon Region
Infect. Immun., November 1, 1999; 67(11): 5906 - 5916.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. Dodoo, T. G. Theander, J. A. L. Kurtzhals, K. Koram, E. Riley, B. D. Akanmori, F. K. Nkrumah, and L. Hviid
Levels of Antibody to Conserved Parts of Plasmodium falciparum Merozoite Surface Protein 1 in Ghanaian Children Are Not Associated with Protection from Clinical Malaria
Infect. Immun., May 1, 1999; 67(5): 2131 - 2137.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Barragan, P. G. Kremsner, W. Weiss, M. Wahlgren, and J. Carlson
Age-Related Buildup of Humoral Immunity against Epitopes for Rosette Formation and Agglutination in African Areas of Malaria Endemicity
Infect. Immun., October 1, 1998; 66(10): 4783 - 4787.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Society of Tropical Medicine and Hygiene.