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Am. J. Trop. Med. Hyg., 58(2), 1998, pp. 192-194
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 58, Issue 2, 192-194
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


Short report: detection of Leishmaniavirus in human biopsy samples of leishmaniasis from Peru

M Saiz, A Llanos-Cuentas, J Echevarria, N Roncal, M Cruz, MT Muniz, C Lucas, DF Wirth, S Scheffter, AJ Magill, and JL Patterson

Leishmaniavirus is a double-stranded RNA virus that persistently infects some strains of the protozoan parasite Leishmania. There is considerable interest in the possibility that the presence of this virus alters parasite phenotype and may affect disease pathogenesis. If so, the virus marker could provide a valuable prognostic indicator for human leishmaniasis, particularly in those cases caused by New World parasite strains. The virus has been detected in cultured L. braziliensis, L. b. guyanensis, and L. major. To date there has been no information as to the extent of infection in samples prior to culturing in the laboratory. This study demonstrates, through the reverse transcription-polymerase chain reaction, that Leishmaniavirus exists in human biopsy samples of leishmaniasis prior to manipulation in culture.


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M. M. OGG, R. CARRION JR., A. C. DE CARVALHO BOTELHO, W. MAYRINK, R. CORREA-OLIVEIRA, and J. L. PATTERSON
SHORT REPORT: QUANTIFICATION OF LEISHMANIAVIRUS RNA IN CLINICAL SAMPLES AND ITS POSSIBLE ROLE IN PATHOGENESIS
Am J Trop Med Hyg, September 1, 2003; 69(3): 309 - 313.
[Abstract] [Full Text] [PDF]


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Copyright © 1998 by the American Society of Tropical Medicine and Hygiene.