AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 58(1), 1998, pp. 11-16
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sabchareon, A
Right arrow Articles by Chongsuphajaisiddhi, T
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sabchareon, A
Right arrow Articles by Chongsuphajaisiddhi, T
Related Collections
Right arrow Malaria
Right arrow Plasmodium
American Journal of Tropical Medicine and Hygiene, Vol 58, Issue 1, 11-16
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


Comparative clinical trial of artesunate suppositories and oral artesunate in combination with mefloquine in the treatment of children with acute falciparum malaria

A Sabchareon, P Attanath, P Chanthavanich, P Phanuaksook, V Prarinyanupharb, Y Poonpanich, D Mookmanee, P Teja-Isavadharm, DG Heppner, TG Brewer, and T Chongsuphajaisiddhi

A randomized pilot study to compare the safety and efficacy of artesunate suppositories (15 mg/kg/day for three days) versus oral artesunate (6 mg/kg/day for three days), both in combination with mefloquine (25 mg/kg), was conducted in 52 Thai children with uncomplicated multidrug-resistant falciparum malaria. Forty-five patients (87%) had a full 28-day follow-up in the hospital to assess efficacy and exclude reinfection. Mean [range] times to fever clearance of the two groups were similar (42 hr [15-104] versus 42 hr [6-119]). Artesunate suppositories resulted in significantly longer times to achieve 50% and 90% reductions of the initial parasite counts (17 and 26 hr versus 9 and 15 hr; P < 0.05 and P < 0.001). Time [range] to parasite clearance was longer in the artesunate suppositories group (42 hr [14-93] versus 35 hr [16-69]), but the difference was not significant. The cure rates by days 28 were not significantly different, 92% for artesunate suppository-treated patients and 100% for oral artesunate-treated patients. Both drug regimens are safe and effective. Further studies are needed to characterize the pharmacokinetic properties and the optimum regimen of artesunate suppositories for the treatment of severe malaria.


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
N. Day and A. M. Dondorp
The Management of Patients with Severe Malaria
Am J Trop Med Hyg, December 1, 2007; 77(6_Suppl): 29 - 35.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
H. A. Karunajeewa, L. Manning, I. Mueller, K. F. Ilett, and T. M. E. Davis
Rectal Administration of Artemisinin Derivatives for the Treatment of Malaria
JAMA, June 6, 2007; 297(21): 2381 - 2390.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
H. A. Karunajeewa, J. Reeder, K. Lorry, E. Dabod, J. Hamzah, M. Page-Sharp, G. M. Chiswell, K. F. Ilett, and T. M. E. Davis
Artesunate Suppositories versus Intramuscular Artemether for Treatment of Severe Malaria in Children in Papua New Guinea
Antimicrob. Agents Chemother., March 1, 2006; 50(3): 968 - 974.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
H. A. Karunajeewa, K. F. Ilett, K. Dufall, A. Kemiki, M. Bockarie, M. P. Alpers, P. H. Barrett, P. Vicini, and T. M. E. Davis
Disposition of Artesunate and Dihydroartemisinin after Administration of Artesunate Suppositories in Children from Papua New Guinea with Uncomplicated Malaria
Antimicrob. Agents Chemother., August 1, 2004; 48(8): 2966 - 2972.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
S. Krishna, T. Planche, T. Agbenyega, C. Woodrow, D. Agranoff, G. Bedu-Addo, A. K. Owusu-Ofori, J. A. Appiah, S. Ramanathan, S. M. Mansor, et al.
Bioavailability and Preliminary Clinical Efficacy of Intrarectal Artesunate in Ghanaian Children with Moderate Malaria
Antimicrob. Agents Chemother., February 1, 2001; 45(2): 509 - 516.
[Abstract] [Full Text]

Home page
 Antimicrob. Agents Chemother.Home page
T. Akompong, S. Eksi, K. Williamson, and K. Haldar
Gametocytocidal Activity and Synergistic Interactions of Riboflavin with Standard Antimalarial Drugs against Growth of Plasmodium falciparum In Vitro
Antimicrob. Agents Chemother., November 1, 2000; 44(11): 3107 - 3111.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Society of Tropical Medicine and Hygiene.