AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 57(5), 1997, pp. 507-511
Copyright © 1997 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dondorp, A. M.
Right arrow Articles by Vreeken, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dondorp, A. M.
Right arrow Articles by Vreeken, J.

Prognostic Significance of Reduced Red Blood Cell Deformability in Severe Falciparum Malaria

Adrianus M. Dondorp, Brian J. Angus, Max R. Hardeman, Kesinee T. Chotivanich, Kamdrat Silamut, Ronatrai Ruangveerayuth, Piet A. Kager, Nicholas J. White AND Johan Vreeken
Department of Internal Medicine and Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, Amsterdam, The Netherlands; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Medicine, Mae Sot Hospital, Mae Sot, Thailand; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, United Kingdom

Severe falciparum malaria is associated with microvascular obstruction resulting from sequestration of erythrocytes containing mature stages of the parasite. Since reduced red blood cell deformability (RBC-D) can contribute to impaired microcirculatory flow, RBC-D was measured in 23 patients with severe falciparum malaria (seven of whom subsequently died), 30 patients with uncomplicated malaria, and 17 healthy controls. The RBC-D, measured by ektacytometry, was significantly reduced in severe malaria and was particularly low in all fatal cases. At a low shear stress of 1.7 Pascal (Pa), a red blood cell elongation index less than 0.21 on admission to the hospital predicted fatal outcome with a sensitivity of 100% (confidence interval [CI] = 59–100%) and a specificity of 88% (CI = 61–98%). The reduction in the RBC-D appeared to result mainly from changes in unparasitized erythrocytes. Reduced deformability of unparasitized red blood cells in severe malaria may contribute to impaired microcirculatory flow and a fatal outcome in severe falciparum malaria.




This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
F. Nuchsongsin, K. Chotivanich, P. Charunwatthana, O.-S. Fausta, D. Taramelli, N. P. Day, N. J. White, and A. M. Dondorp
Effects of Malaria Heme Products on Red Blood Cell Deformability
Am J Trop Med Hyg, October 1, 2007; 77(4): 617 - 622.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. A. Lamikanra, D. Brown, A. Potocnik, C. Casals-Pascual, J. Langhorne, and D. J. Roberts
Malarial anemia: of mice and men
Blood, July 1, 2007; 110(1): 18 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Martini, I. Gramaglia, M. Intaglietta, and H. C. van der Heyde
Impairment of Functional Capillary Density but Not Oxygen Delivery in the Hamster Window Chamber during Severe Experimental Malaria
Am. J. Pathol., February 1, 2007; 170(2): 505 - 517.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
N A V Beare, C E Riva, T E Taylor, M E Molyneux, K Kayira, V A White, S Lewallen, and S P Harding
Changes in optic nerve head blood flow in children with cerebral malaria and acute papilloedema.
J. Neurol. Neurosurg. Psychiatry, November 1, 2006; 77(11): 1288 - 1290.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Spolarics, M. R. Condon, M. Siddiqi, G. W. Machiedo, and E. A. Deitch
Red blood cell dysfunction in septic glucose-6-phosphate dehydrogenase-deficient mice
Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2118 - H2126.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. R. Condon, J. E. Kim, E. A. Deitch, G. W. Machiedo, and Z. Spolarics
Appearance of an erythrocyte population with decreased deformability and hemoglobin content following sepsis
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2177 - H2184.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American Society of Tropical Medicine and Hygiene.