HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sidjanski, S. Articles by Vanderberg, J. P. Search for Related Content PubMed PubMed Citation Articles by Sidjanski, S. Articles by Vanderberg, J. P.

Delayed Migration of Plasmodium Sporozoites from the Mosquito Bite Site to the Blood

Studies were done on delivery of Plasmodium yoelii sporozoites by Anopheles stephensi into the skin of BALB/C mice. When infected mosquitoes fed on a portion of the ear, 81% of these positive control mice developed parasitemia. When the fed-upon site was excised immediately or 5 min postfeeding, a highly significant, smaller percentage of these experimental mice developed parasitemia. When the delay in removal of mosquito-bitten tissue was extended to 15 min, no significant difference was found between this group and positive control mice. These findings show that mosquito-injected sporozoites tend to remain at the bite site for at least 5 min after the mosquito bite. By approximately 15 min, the first wave of migrating sporozoites has left the bite site and moved into the general circulation. These findings have implications concerning possible host obstruction of sporozoite migration in skin by either anti-sporozoite antibodies or by a cutaneous hypersensitivity reaction to mosquito bite.

This article has been cited by other articles:

				S. Yoshida, M. Kawasaki, N. Hariguchi, K. Hirota, and M. Matsumoto A Baculovirus Dual Expression System-Based Malaria Vaccine Induces Strong Protection against Plasmodium berghei Sporozoite Challenge in Mice Infect. Immun., May 1, 2009; 77(5): 1782 - 1789. [Abstract] [Full Text] [PDF]

				Y. Jin, C. Kebaier, and J. Vanderberg Direct Microscopic Quantification of Dynamics of Plasmodium berghei Sporozoite Transmission from Mosquitoes to Mice Infect. Immun., November 1, 2007; 75(11): 5532 - 5539. [Abstract] [Full Text] [PDF]

				J. Vanderberg, A.-K. Mueller, K. Heiss, K. Goetz, K. Matuschewski, M. Deckert, and D. Schluter Assessment of Antibody Protection against Malaria Sporozoites Must Be Done by Mosquito Injection of Sporozoites Am. J. Pathol., October 1, 2007; 171(4): 1405 - 1406. [Full Text] [PDF]

				C. KEBAIER and J. P. VANDERBERG RE-INGESTION OF PLASMODIUM BERGHEI SPOROZOITES AFTER DELIVERY INTO THE HOST BY MOSQUITOES Am J Trop Med Hyg, December 1, 2006; 75(6): 1200 - 1204. [Abstract] [Full Text] [PDF]

				P. Bhanot, K. Schauer, I. Coppens, and V. Nussenzweig A Surface Phospholipase Is Involved in the Migration of Plasmodium Sporozoites through Cells J. Biol. Chem., February 25, 2005; 280(8): 6752 - 6760. [Abstract] [Full Text] [PDF]

				A. Barragan and L. D. Sibley Transepithelial Migration of Toxoplasma gondii Is Linked to Parasite Motility and Virulence J. Exp. Med., June 17, 2002; 195(12): 1625 - 1633. [Abstract] [Full Text] [PDF]