AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 57(2), 1997, pp. 240-244
Copyright © 1997 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hardy, J. L.
Right arrow Articles by Reeves, W. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hardy, J. L.
Right arrow Articles by Reeves, W. C.

Mouse and Baby Chicken Virulence of Enzootic Strains of Western Equine Encephalomyelitis Virus from California

James L. Hardy*, Sally B. Presser, Robert E. Chiles AND William C. Reeves
Arbovirus Research Program, School of Public Health, University of California, Berkeley, California

Eight enzootic strains of western equine encephalomyelitis (WEE) virus isolated from Culex tarsalis or Aedes melanimon collected in several geographic areas of California were evaluated for their virulence in suckling mice, adult mice, and one-day-old baby chickens. The epidemic Fleming strain and the cloned B628(Cl 15) variant were used as virulent and avirulent control viruses, respectively, in adult mice. Enzootic strains of WEE virus were grouped into three phenotypes on the basis of their neurovirulent and neuroinvasive properties in adult mice. Three strains possessed high neurovirulence and were neuroinvasive; three strains had intermediate neurovirulence and lacked neuroinvasiveness; and two strains had low to nil neurovirulence and were non-neuroinvasive. In fact, five of the eight enzootic strains lacked neuroinvasiveness. Interestingly, highly virulent enzootic strains of WEE virus were isolated from Cx. tarsalis collected in the Sacramento Valley during 1994 and 1995 in the absence of identified human disease. The Fleming strain, the B628(Cl 15) variant, and four enzootic strains from the Sacramento Valley were virulent for baby chickens following subcutaneous inoculation. Thus, inoculation into baby chicks cannot discriminate between WEE viruses that are virulent and avirulent for adult mice.


* Deceased




This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
W. K. Reisen, Y. Fang, and A. C. Brault
Limited Interdecadal Variation in Mosquito (Diptera: Culicidae) and Avian Host Competence for Western Equine Encephalomyelitis Virus (Togaviridae: Alphavirus)
Am J Trop Med Hyg, April 1, 2008; 78(4): 681 - 686.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American Society of Tropical Medicine and Hygiene.