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Am. J. Trop. Med. Hyg., 57(1), 1997, pp. 25-30
Copyright © 1997 by The American Society of Tropical Medicine and Hygiene

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*MEBENDAZOLE

Failure of Mebendazole in Treatment of Human Hookworm Infections in the Southern Region of Mali

Dick De Clercq, Moussa Sacko, Jerzy Behnke, Francis Gilbert, Pierre Dorny AND Jozef Vercruysse
Institut National de Recherche en Sante Publique (INRSP), Service de Parasitologie, Project Universiteit Gent-INRSP, Bamako-Coura, Mali; Department of Parasitology, Faculty of Veterinary Medicine, University of Gent, Gent, Merelbeke, Belgium; Experimental Parasitology Research Group, and Behaviour and Ecology Research Group, Department of Life Science, University of Nottingham, University Park, Nottingham, United Kingdom

Preliminary studies indicated that single-dose (500 mg) mebendazole gave disappointing results in the treatment of hookworm infections (Necator americanus) in Mali. A placebo-controlled, randomized trial conducted with the participation of 103 infected subjects (background hookworm prevalence > 50%) confirmed that mebendazole (Vermox®) did not reduce parasite burdens significantly, as assessed through fecal egg counts. In contrast, a group of subjects treated with pyrantel (Combantrin®) experienced a significant reduction in fecal worm egg counts (overall, both sexes combined showed a 75% reduction). Male subjects carried significantly more intense infections compared with females, but there was no gender difference in response to treatment. A standard egg hatch assay showed that N. americanus from our subjects in Mali was more resistant to benzimidazoles compared with a laboratory-maintained strain that had not been exposed to anthelmintics in more than 100 generations (50% effective dose = 0.12 and 0.07 µg/ml of thiabendazole, respectively), suggesting that, among other possibilities, the development of resistance to the benzimidazoles by N. americanus may have contributed to the drug failure. Whatever the underlying explanation, our results indicate that single-dose treatment with mebendazole is an ineffective treatment for hookworm infections and despite its relatively cheap cost and wide availability, mebendazole should not be considered a drug of choice in the mass treatment of hookworm infections in this region of Mali.




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Copyright © 1997 by the American Society of Tropical Medicine and Hygiene.