AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 56(6), 1997, pp. 627-631
Copyright © 1997 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baird, J. K.
Right arrow Articles by Subianto, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baird, J. K.
Right arrow Articles by Subianto, B.

In Vivo Resistance to Chloroquine by Plasmodium vivax and Plasmodium falciparum at Nabire, Irian Jaya, Indonesia

J. K. Baird, I. Wiady, D. J. Fryauff, M. A. Sutanihardja, B. Leksana, H. Widjaya, Kysdarmanto AND B. Subianto
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia; Regional Health Clinic, Uwapa, Irian Jaya, Indonesia; Provincial Health Service, Jayapura, Irian Jaya, Indonesia

A survey of resistance to chloroquine by Plasmodium vivax and P. falciparum was conducted during May 1995 at three mesoendemic villages 30 km southeast of Nabire, near the central northern coast of Irian Jaya, Indonesia. The prevalence of malaria at Urusumu (n = 157), Margajaya (n = 573), and Topo (n = 199) was 18%, 9%, and 9%, respectively, with spleen rates among children of 79%, 10%, and 27%. Infected patients among those screened formed a study population of 64 subjects eligible for a 28-day in vivo test of resistance to chloroquine. Sixty-three patients successfully completed the test; 45 males and 18 females 1–60 years of age, of whom 29 were Javanese transmigrants of five years residence in Irian Jaya and 34 were native to Irian Jaya. The seven-day day cumulative incidence of therapeutic failure for P. vivax and P. falciparum was 15% (n = 34) and 30% (n = 37). The 14- and 28-day estimates of cumulative incidence were 45% and 64% for P. vivax and 58% and 89% for P. falciparum. Almost all recurrences appeared in the face of ordinarily effective levels of chloroquine and its major metabolite, desethylchloroquine, in whole blood (≥ 100 ng/ml). Four infections by P. malariae in subjects enrolled in this study cleared by day 2 and none reappeared within 28 days. Chloroquine no longer provides effective therapy for falciparum or vivax malaria along the northern coast of Irian Jaya, Indonesia.




This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
S. Krudsood, N. Tangpukdee, P. Wilairatana, N. Phophak, J. K. Baird, G. M. Brittenham, and S. Looareesuwan
High-dose Primaquine Regimens against Relapse of Plasmodium vivax Malaria
Am J Trop Med Hyg, May 1, 2008; 78(5): 736 - 740.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
K. S. Griffith, L. S. Lewis, S. Mali, and M. E. Parise
Treatment of Malaria in the United States: A Systematic Review
JAMA, May 23, 2007; 297(20): 2264 - 2277.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
A. AULIFF, D. W. WILSON, B. RUSSELL, Q. GAO, N. CHEN, L. N. ANH, J. MAGUIRE, D. BELL, M. T. O'NEIL, and Q. CHENG
AMINO ACID MUTATIONS IN PLASMODIUM VIVAX DHFR AND DHPS FROM SEVERAL GEOGRAPHICAL REGIONS AND SUSCEPTIBILITY TO ANTIFOLATE DRUGS.
Am J Trop Med Hyg, October 1, 2006; 75(4): 617 - 621.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. P. Daily and M. A. Waldron
Case 22-2003 - A 22-Year-Old Man with Chills and Fever after a Stay in South America
N. Engl. J. Med., July 17, 2003; 349(3): 287 - 295.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American Society of Tropical Medicine and Hygiene.