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Am. J. Trop. Med. Hyg., 56(5), 1997, pp. 566-572
Copyright © 1997 by The American Society of Tropical Medicine and Hygiene

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Risk Factors in Dengue Shock Syndrome

Soe Thein, Myo Min Aung, Than Nu Shwe, Myo Aye, Aung Zaw, Kathy Aye, Khin Mar Aye AND John Aaskov
Virology Research Division, Department of Medical Research and Yangon Children's Hospital, Yangon, Myanmar; World Health Organization Collaborative Centre for Arbovirus Reference and Research, School of Life Science, Queensland University of Technology, Brisbane, Australia

Despite a growing body of evidence predominantly, but not exclusively, from Thailand suggesting that the risk of developing dengue shock syndrome (DSS) is greatest following an anamnestic dengue infection, particularly if the most recent infection was with dengue 2 virus, there continues to be debate about the justification for these claims. This report describes a five-year, prospective study in two townships (suburbs) in Yangon (Rangoon) Myanmar (Burma) in which attempts were made to confirm the data from an earlier prospective study in Thailand and to address some of the criticism of earlier studies. This investigation found the incidence of anamnestic dengue infections in DSS patients to be significantly higher than in the community from which they were drawn and a significantly higher risk of developing DSS following an anamnestic infection (particularly with dengue 2 virus) than following a primary infection with any serotype.




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Copyright © 1997 by the American Society of Tropical Medicine and Hygiene.