AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 56(2), 1997, pp. 235-240
Copyright © 1997 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schlagenhauf, P.
Right arrow Articles by Crevoisier, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schlagenhauf, P.
Right arrow Articles by Crevoisier, C.

Tolerance of Mefloquine by Swissair Trainee Pilots

Patricia Schlagenhauf, Hans Lobel, Robert Steffen, Richard Johnson, Kathryn Popp, Alois Tschopp, Richard Letz AND Charles Crevoisier
Division of Communicable Diseases, and Division of Biostatistics, Institute for Social and Preventive Medicine, University of Zurich, Zurich, Switzerland; Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts; Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, District of Columbia; Rollins School of Public Health of Emory University, Atlanta, Georgia; Department of Clinical Pharmacology, F. Hoffmann-La Roche Ltd., Basel, Switzerland

Due to presumed adverse performance impact, a World Health Organization clause currently restricts the use of mefloquine malaria chemoprophylaxis in individuals requiring fine coordination and spatial discrimination. We conducted a double-blind, placebo-controlled, cross-over study to quantitatively assess the effects of mefloquine at steady state on performance in 23 trainee airline pilots. Flying performance was assessed using a flight simulator, psychomotor function was evaluated, sleep and wake cycles were monitored, and symptoms and moods were assessed using standardized questionnaires. A simplified postural sway meter recorded sway in three test positions. In the mefloquine loading dose phase, there was one withdrawal due to dizziness, diarrhea, and flu-like symptoms, and three volunteers reported nonserious, sleep-related adverse events. There was no significant difference in flying performance, psychomotor functions, or mean sway for any test position. Nonsignificant reductions in mean total nocturnal sleep (mefloquine = 450 min versus placebo = 484 min) and poorer sleep quality were detected in the mefloquine phases. The mood findings indicated a predominance of positive states, with vigor the predominant mood in all phases. No significant performance deficit was documented under laboratory conditions during use of mefloquine at steady state.




This article has been cited by other articles:


Home page
 JAMAHome page
L. H. Chen, M. E. Wilson, and P. Schlagenhauf
Controversies and Misconceptions in Malaria Chemoprophylaxis for Travelers
JAMA, May 23, 2007; 297(20): 2251 - 2263.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
L. H. Chen, M. E. Wilson, and P. Schlagenhauf
Prevention of malaria in long-term travelers.
JAMA, November 8, 2006; 296(18): 2234 - 2244.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American Society of Tropical Medicine and Hygiene.