AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 56(2), 1997, pp. 231-234
Copyright © 1997 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smoak, B. L.
Right arrow Articles by Wellde, B. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smoak, B. L.
Right arrow Articles by Wellde, B. T.

Plasmodium vivax Infections in U.S. Army Troops: Failure of Primaquine to Prevent Relapse in Studies from Somalia

Bonnie L. Smoak, Robert F. DeFraites, Alan J. Magill, Kevin C. Kain AND Bruce T. Wellde
Division of Preventive Medicine and Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Washington, District of Columbia; Tropical Disease Unit, The Toronto Hospital, Toronto, Ontario, Canada

Different strains of Plasmodium vivax vary in their sensitivity to primaquine, the only drug that prevents relapses. Described are the clinical data and relapse pattern for 75 soldiers treated for vivax malaria since returning from Somalia. Following their initial attack of malaria, 60 of the 75 cases received a standard course of primaquine (15 mg base daily for 14 days). Twenty-six of the 60 soldiers subsequently relapsed for a failure rate of 43%. Eight soldiers had a second relapse following primaquine therapy after both the primary attack and first relapse. Three of these soldiers had received a higher dosage of primaquine (30 mg base daily for 14 days) after their second attack. The apparent ineffectiveness of primaquine therapy in preventing relapses suggests the presence of primaquine-resistant* P. vivax strains in Somalia.


* Editor's footnote: The issue of primaquine resistance versus tolerance has been addressed in a recent article in the American Journal of Tropical Medicine and Hygiene (Collins WE, Jeffery GM, 1996. Primaquine resistance in Plasmodium vivax. Am J Trop Med Hyg 55: 243–249).




This article has been cited by other articles:


Home page
 Clin. Microbiol. Rev.Home page
J. K. Baird
Resistance to Therapies for Infection by Plasmodium vivax
Clin. Microbiol. Rev., July 1, 2009; 22(3): 508 - 534.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
L. H. Chen, M. E. Wilson, and P. Schlagenhauf
Controversies and Misconceptions in Malaria Chemoprophylaxis for Travelers
JAMA, May 23, 2007; 297(20): 2251 - 2263.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
J. L. GOLLER, D. JOLLEY, P. RINGWALD, and B.-A. BIGGS
REGIONAL DIFFERENCES IN THE RESPONSE OF PLASMODIUM VIVAX MALARIA TO PRIMAQUINE AS ANTI-RELAPSE THERAPY
Am J Trop Med Hyg, February 1, 2007; 76(2): 203 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
D. R. HILL, J. K. BAIRD, M. E. PARISE, L. S. LEWIS, E. T. RYAN, and A. J. MAGILL
PRIMAQUINE: REPORT FROM CDC EXPERT MEETING ON MALARIA CHEMOPROPHYLAXIS I.
Am J Trop Med Hyg, September 1, 2006; 75(3): 402 - 415.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. S. Kotwal, R. B. Wenzel, R. A. Sterling, W. D. Porter, N. N. Jordan, and B. P. Petruccelli
An Outbreak of Malaria in US Army Rangers Returning From Afghanistan
JAMA, January 12, 2005; 293(2): 212 - 216.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American Society of Tropical Medicine and Hygiene.