HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wyler, D. J. Articles by Talebian, P. Search for Related Content PubMed PubMed Citation Articles by Wyler, D. J. Articles by Talebian, P.

A Quantitative Assay to Detect Circulating Fibrosin and Its Application in Experimental Schistosomiasis

The molecular pathogenesis of schistosomal liver fibrosis has been studied in a murine model of Schistosoma mansoni. A novel fibroblast growth factor, fibrosin, was identified as a product of a subpopulation of CD4⁺ lymphocytes resident in the hepatic egg granulomas. We describe a sensitive, quantitative, antigen-capture enzymelinked immunosorbent assay that can detect fibrosin in mouse serum and plasma at concentrations > 0.05 pg/ml. Using this assay, we detected in infected mice circulating fibrosin levels that were several fold increased above those detected in uninfected controls. Circulating fibrosin levels increased after week 4 of infection, reached a peak at week 8, and normalized by week 12. We propose that circulating fibrosin might be a useful marker of hepatic fibrogenesis in schistosomiasis.

This article has been cited by other articles:

				A. G.P. Ross, P. B. Bartley, A. C. Sleigh, G. R. Olds, Y. Li, G. M. Williams, and D. P. McManus Schistosomiasis N. Engl. J. Med., April 18, 2002; 346(16): 1212 - 1220. [Full Text] [PDF]