AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 55(6), 1996, pp. 652-654
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene

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Migration of Leishmania donovani Amastigotes in the Cerebrospinal Fluid

Lala S. N. Prasad AND Sandeep Sen
Sen Medical Research Centre, Patna, India

A 10-year-old boy had been suffering from kala-azar (visceral leishmaniasis) for two and a half years. He failed to respond to all known anti-leishmanial treatment regimens. Even the drastic step of splenectomy failed to cure him. In November 1991, he presented with symptoms of meningitis. A diagnostic lumbar puncture revealed leishmanial amastigotes in his cerebrospinal fluid. The patient was finally cured with a course of amphotericin B, a drug known to cross the blood-brain barrier.






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Copyright © 1996 by the American Society of Tropical Medicine and Hygiene.