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Am. J. Trop. Med. Hyg., 55(5), 1996, pp. 474-476
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene

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Short Report: Long-Term Serum Antibody Isotype Responses to Strongyloides stercoralis Filariform Antigens in Eight Patients Treated with Ivermectin

John F. Lindo, Neil S. Atkins, Michael G. Lee, Ralph D. Robinson AND Donald A. P. Bundy
Departments of Microbiology, Medicine, and Zoology, The University of the West Indies, Kingston, Jamaica; Centre for the Epidemiology of Infectious Disease, University of Oxford, Oxford, United Kingdom

The enzyme-linked immunosorbant assay was used to investigate long-term changes in serum immunoglobulin G1 (IgG1), IgG4, IgE, and IgA against Strongyloides stercoralis phosphate-buffered saline-soluble filariform larval antigens in eight Jamaican patients treated with ivermectin. Patients were followed for periods of between 170 and 542 days. Based on repeated formalin-ether concentration and agar plate culture, all patients were found to be uninfected up to 18 months following chemotherapy. Generally, all antibody isotype levels decreased following treatment, although there was considerable heterogeneity among patients. In a single patient with hyperinfection, the decrease in IgG4 was marginal and may represent a treatment failure. Reduction in serum antibody isotype responses to S. stercoralis following treatment may be used to assess the effectiveness of ivermectin in treating endemic strongyloidiasis.




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Copyright © 1996 by the American Society of Tropical Medicine and Hygiene.