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Am. J. Trop. Med. Hyg., 55(4), 1996, pp. 365-369
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene

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Immunocytochemical and Histopathologic Characterization of Lesions from Patients with Localized Cutaneous Leishmaniasis Caused by Leishmania Panamensis

Diana M. Isaza, Marcos Restrepo, Rodrigo Restrepo, Gisela Caceres-Dittmar AND Felix J. Tapia
Instituto Colombiano de Medicina Tropical, Medellin, Colombia; Facultad de Medicina, Universidad Pontificia Bolivariana, Medellin, Colombia; Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela

Localized cutaneous leishmaniasis (LCL) in Colombia is caused primarily by Leishmania panamensis, a different species from those reported in Brazil, French Guiana, and Venezuela. Because different parasites may elicit disparate immune responses, the present study was undertaken to establish the leukocyte participation in the immune response against L. panamensis. Epidermal and dermal immune complexes were studied using an avidinbiotin immunoperoxidase technique and specific monoclonal antibodies. In LCL, the epidermis showed keratinocytes expressing intercellular adhesion molecule-1, a universal expression of human leukocyte antigen-DR, and a hyperplasia of CD1a+ Langerhans cells. The dermal granuloma observed had a mean ± SEM value for the CD4/CD8 ratio of 0.80 ± 0.06. The expression of the activation molecules CD25 (interleukin-2 receptor) and CD18 (lymphocyte function-associated antigen-1ß), 10.5% and 38.1% respectively, suggests that many cells are primed and proliferating. Most T cells in the granuloma expressed {alpha}ß T cell receptor (TCR) (40.3%) whereas only a few (6.7%) expressed {gamma}{delta} TCR. The results show that Colombian LCL patients possessed the appropriate activation and accessory signals from immunocompetent cells to trigger the effector phase of the immune response and eventually eliminate the parasite.




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Copyright © 1996 by the American Society of Tropical Medicine and Hygiene.