AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 54(6), 1996, pp. 652-654
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene

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Gametocytocidal Activity of {alpha}/ß Arteether by the Oral Route of Administration

Renu Tripathi, G. P. Dutta AND R. A. Vishwakarma
Division of Microbiology, Central Drug Research Institute, Lucknow, India; National Institute of Immunology, New Delhi, India

Arteether ({alpha}/ß) (a mixture of {alpha} and ß enantioners) has been reported to possess gametocytocidal activity against Plasmodium cynomolgi B when the drug is given by the intramuscular route, but it would be preferable to use oral route therapy for gametocyte carriers. This is a report of a study of the gametocytocidal action of arteether administered by the oral route. The results indicate high levels of activity at 10 mg/kg in a single dose or in two divided doses when given orally.






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Copyright © 1996 by the American Society of Tropical Medicine and Hygiene.