AJTMH Tropical Medicine and Hygiene News
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 54(6), 1996, pp. 586-590
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kardorff, R.
Right arrow Articles by Gryseels, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kardorff, R.
Right arrow Articles by Gryseels, B.

Ultrasonography in a Senegalese Community Recently Exposed to Schistosoma mansoni Infection

Ruediger Kardorff, Foekje F. Stelma, Anna-K. Vocke, Yazdan Yazdanpanah, Anna K. Thomas, Amadou Mbaye, Idrissa Talla, Malick Niang, Jochen H. H. Ehrich, Ekkehard Doehring AND Bruno Gryseels
Department of Pediatrics, Medizinische Hochschule Hannover, Hannover, Germany; Laboratory of Parasitology, University of Leiden, Leiden, The Netherlands; Institut Pasteur, Lille, France; District Sanitaire de Richard Toll, Richard Toll, Senegal; Service Regional de la Sante, Saint Louis/Richard Toll, Senegal; Humboldt University, Charite, Berlin, Germany; Interdisziplinaeres Therapiezentrum, Feldberg, Germany; Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium

Inhabitants of Ndombo (n = 614), a village in an area recently infected with Schistosoma mansoni in Northern Senegal, were examined clinically, parasitologically, and ultrasonographically to investigate the presence and degree of S. mansoni-related hepatosplenic morbidity after a few years of exposure to schistosomal infection of regional canals. Despite previous praziquantel treatment of 56% of the inhabitants prior to our investigation, the prevalence of S. mansoni infection in 1993 was 90%, and 42% of the villagers excreted more than 1,000 eggs per gram of stool. Previously untreated individuals were found to have significantly higher egg counts than treated ones. Despite the high intensities of infection, ultrasonographically detected severe periportal thickening of the liver was infrequent. Grading according to body length-dependent normal values of cross-section diameter of peripheral portal vein branches of a European control group correlated with intensities of infection. Of the total group of patients, 30% (n = 182) had more severe thickening of portal vein branch diameters above the 97th percentile and 70% of these had a splenomegaly. The highest egg counts and the most frequent development of periportal thickening were found in 11–20 year-old individuals. Periportal thickening was less frequent in praziquantel-treated adolescents than in untreated ones. This suggests that early antischistosomal medication may be useful to limit schistosomiasis-induced hepatic morbidity especially in children, even though reinfection seems inevitable.




This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
A. KOUKOUNARI, M. SACKO, A. D. KEITA, A. F. GABRIELLI, A. LANDOURE, R. DEMBELE, A. C. CLEMENTS, S. WHAWELL, C. A. DONNELLY, A. FENWICK, et al.
ASSESSMENT OF ULTRASOUND MORBIDITY INDICATORS OF SCHISTOSOMIASIS IN THE CONTEXT OF LARGE-SCALE PROGRAMS ILLUSTRATED WITH EXPERIENCES FROM MALIAN CHILDREN
Am J Trop Med Hyg, December 1, 2006; 75(6): 1042 - 1052.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the American Society of Tropical Medicine and Hygiene.