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Am. J. Trop. Med. Hyg., 54(2), 1996, pp. 203-204
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene

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Short Report: Severe Hiccups Secondary to Doxycycline-Induced Esophagitis during Treatment of Malaria

Ioanna Tzianetas, Flavio Habal AND Jay S. Keystone
Department of Pharmacy Services, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Gastroenterology, and Tropical Disease Unit, The Toronto Hospital, Toronto, Ontario, Canada

A 51-year-old man who was treated with quinine and doxycycline for Plasmodium falciparum malaria acquired in West Africa developed hiccups soon after his first dose of antimalarial therapy. Endoscopic examination performed when his hiccups became intractable showed an esophageal erosion and ulcer most likely due to doxycycline. The patient's symptoms resolved on treatment with omeprazole and sucralfate.




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J. O'Donnell
Drug-Induced Esophagitis
Journal of Pharmacy Practice, August 1, 2000; 13(4): 290 - 296.
[Abstract] [PDF]




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Copyright © 1996 by the American Society of Tropical Medicine and Hygiene.