AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 53(3), 1995, pp. 256-259
Copyright © 1995 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barral, A.
Right arrow Articles by Carvalho, E. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barral, A.
Right arrow Articles by Carvalho, E. M.

Lymphadenopathy as the First Sign of Human Cutaneous Infection by Leishmania braziliensis

Aldina Barral, Jaqueline Guerreiro, Gloria Bomfim, D. Correia, M. Barral-Netto AND E. M. Carvalho
Servico de Imunologia, Hospital Universitario Prof. Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil; Laboratorio Integrado de Microbiologia e Imuno-Regulacao, Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador, Bahia, Brazil

This paper describes the presence of transitory lymphadenopathy as an initial sign of cutaneous leishmaniasis, and sometimes the only manifestation of Leishmania braziliensis infection. Ten patients with lymphadenopathy living in an area of L. braziliensis transmission had Leishmania cultivated from their lymph nodes previous to any other manifestation of cutaneous leishmaniasis. Seven of the 10 developed leishmanial ulcers later in the course of infection, whereas lymphadenopathy regressed in three cases and no other sign of infection developed. Results of tests for anti-Leishmania antibodies and an intradermal skin test were positive in four and five patients, respectively, at the time of the diagnosis. The documentation of Leishmania amastigotes in the lymph nodes before any clinical evidence of cutaneous disease indicates that early spread of L. braziliensis from the skin to lymph nodes occurs before a local lesion develops. All medical doctors examining patients coming from endemic areas of leishmaniasis should be aware that lymph node enlargement, even in the absence of a typical ulceration, may be indicative of leishmanial infection and warrants further investigation.




This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
G. Bomfim, B. B. Andrade, S. Santos, J. Clarencio, M. Barral-Netto, and A. Barral
Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease
Am J Trop Med Hyg, November 1, 2007; 77(5): 854 - 859.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
F. J. S. Rocha, U. Schleicher, J. Mattner, G. Alber, and C. Bogdan
Cytokines, Signaling Pathways, and Effector Molecules Required for the Control of Leishmania (Viannia) braziliensis in Mice
Infect. Immun., August 1, 2007; 75(8): 3823 - 3832.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Clarencio, C. I. de Oliveira, G. Bomfim, M. M. Pompeu, M. J. Teixeira, T. C. Barbosa, S. Souza-Neto, E. M. Carvalho, C. Brodskyn, A. Barral, et al.
Characterization of the T-Cell Receptor V{beta} Repertoire in the Human Immune Response against Leishmania Parasites.
Infect. Immun., August 1, 2006; 74(8): 4757 - 4765.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American Society of Tropical Medicine and Hygiene.