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Am. J. Trop. Med. Hyg., 52(3), 1995, pp. 241-246
Copyright © 1995 by The American Society of Tropical Medicine and Hygiene

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Partial Nucleotide and Amino Acid Sequences of the Envelope and the Envelope/Nonstructural Protein-1 Gene Junction of Four Dengue-2 Virus Strains Isolated during the 1981 Cuban Epidemic

Maria G. Guzman, Vincent Deubel, Jose L. Pelegrino, Delfina Rosario, Miguel Marrero, Carlos Sariol AND Gustavo Kouri
Virology Department, Pedro Kouri Tropical Medicine Institute, Havana, Cuba; Virology Department, Institut Pasteur, Paris, France

In 1981, an epidemic of dengue hemorrhagic fever (DHF) caused by dengue-2 virus occurred in Cuba. This was the first DHF epidemic reported in the Western Hemisphere. In this study, we have analyzed four dengue-2 Cuba strains for two short genomic fragments: one on the envelope (E) glycoprotein and one at the E/nonstructural protein-1 (NS1) gene junction. The E segment of these 1981 Cuban isolates were more closely related to older dengue-2 virus strains such as New Guinea C 1944, Thailand 1964, Sri Lanka 1968, and Burma 1976 than to more recent isolates of this virus from Jamaica and Vietnam. More than 9% of the divergence with strains isolated from Jamaica and Vietnam was observed at the E/NS1 gene junction. One nucleotide change was observed between the first strain isolated during the epidemic and the rest of the Cuban strains. This mutation induced a nonconserved amino acid change from phenylalanine to leucine at position 43 that was not observed in any of the other strains with which it was compared.




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Copyright © 1995 by the American Society of Tropical Medicine and Hygiene.