AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 51(6), 1994, pp. 791-796
Copyright © 1994 by The American Society of Tropical Medicine and Hygiene

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Filariasis Testing in a Jird Model: New Drug Leads from Some Old Standbys

Kenneth E. Kinnamon, Daniel L. Klayman*, Bing T. Poon, John W. McCall, Michael T. Dzimianski AND Samuel J. Rowan
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia; Department of Parasitology, College of Veterinary Medicine, University of Georgia, Athens, Georgia

A total of 65 compounds, most of which were from chemical classes having members known to be active against one or more parasitic organisms, were evaluated against Brugia pahangi and Acanthocheilonema viteae for macrofilaricidal activity in male Mongolian jirds (Meriones unguiculatus). Sixteen of the 65 compounds tested suppressed the number of parasites. Of these 16, three were suppressive for B. pahangi, 10 for A. viteae, and three for both parasites. The antibiotic nigericin and the antihistaminic isothipendyl were found to be most active.


* Deceased.






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Copyright © 1994 by the American Society of Tropical Medicine and Hygiene.