AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 51(4), 1994, pp. 424-429
Copyright © 1994 by The American Society of Tropical Medicine and Hygiene

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*Bile Duct Diseases

Association of Antibodies to Opisthorchis viverrini with Hepatobiliary Disease in Northeastern Thailand

Makoto Itoh, Chawalit Pairojkul, Witaya Thamawit, Paiboon Sithithaworn, Danai Tiwawech, Thongueb Uttaravicien, Tomoyuki Shirai AND Nobuyuki Ito
Department of Medical Zoology and First Department of Pathology, Nagoya City University Medical School, Kawasumi, Mizuho, Nagoya, Japan; Departments of Pathology, Parasitology, and Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand; Research Division, National Cancer Institute, Bangkok, Thailand

The association between Opisthorchis viverrini infection and hepatobiliary disease was studied in northeastern Thailand. Positive rates of O. viverrini infection and antibody titers to O. viverrini adult worm extracts, which were determined by enzymelinked immunosorbent assay (ELISA), were compared among four groups: Thai patients with cholangiocarcinomas (CHCA), those with calculus cholecystitis (CCLT), endemic area victims of traffic accidents, and Japanese individuals used as negative controls. While no difference was observed between cases with CCLT and the accident victims, the CHCA group showed a significantly higher positivity rate for fluke infection and higher antibody titers than the other groups. Comparison of the positivity rates and ELISA titers among intrahepatic and extrahepatic CHCA subgroups showed that only females with intrahepatic tumors had a low positive rate and significantly lower titers, with no other significant variation being evident. From these observations, a strong association between high intensity of past and/or present O. viverrini infection and the genesis of CHCAs was apparent in the majority of cases. However, in addition to the fluke infection, other unknown exogenous or endogenous factor(s) were suggested in the female cases.




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N R Hughes, C Pairojkul, S G Royce, A Clouston, and P S Bhathal
Liver fluke-associated and sporadic cholangiocarcinoma: an immunohistochemical study of bile duct, peribiliary gland and tumour cell phenotypes
J. Clin. Pathol., October 1, 2006; 59(10): 1073 - 1078.
[Abstract] [Full Text] [PDF]


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Copyright © 1994 by the American Society of Tropical Medicine and Hygiene.