AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 51(1), 1994, pp. 102-108
Copyright © 1994 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Elliott, L. H.
Right arrow Articles by Peters, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Elliott, L. H.
Right arrow Articles by Peters, C. J.

Isolation of the Causative Agent of Hantavirus Pulmonary Syndrome

L. H. Elliott, T. G. Ksiazek, P. E. Rollin, C. F. Spiropoulou, S. Morzunov, M. Monroe, C. S. Goldsmith, C. D. Humphrey, S. R. Zaki, J. W. Krebs, G. Maupin, K. Gage, J. E. Childs, S. T. Nichol AND C. J. Peters
Special Pathogens Branch, Molecular Pathology and Ultrastructure Activities, Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, and Division of Vector-Borne Infectious Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia and Fort Collins, Colorado

Investigation of a recent outbreak of acute respiratory illness in the southwestern United States resulted in the recognition of a new disease, hantavirus pulmonary syndrome (HPS) with high mortality. Different animals and cell lines were used in attempts to isolate the causative agent. A previously unknown hantavirus was passaged in laboratory-bred deer mice, recovered from lung tissues of a deer mouse, Peromyscus maniculatus, and propagated in the E6 clone of Vero cells. Virus antigen was readily detected in the infected cells by an indirect immunofluorescence assay, using convalescent-phase sera from HPS patients. By electron microscopy, the virus was shown to have the typical morphologic features of members of the genus Hantavirus, family Bunyaviridae. Virus sequences corresponded to those previously detected by a nested reverse transcriptase-polymerase chain reaction assay of hantavirus-infected specimens from rodents and humans. This newly recognized virus, the etiologic agent of HPS, has been tentatively named Muerto Canyon virus.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
J. B. Prescott, P. R. Hall, V. S. Bondu-Hawkins, C. Ye, and B. Hjelle
Early Innate Immune Responses to Sin Nombre Hantavirus Occur Independently of IFN Regulatory Factor 3, Characterized Pattern Recognition Receptors, and Viral Entry
J. Immunol., August 1, 2007; 179(3): 1796 - 1802.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. K. Rowe and A. Pekosz
Bidirectional Virus Secretion and Nonciliated Cell Tropism following Andes Virus Infection of Primary Airway Epithelial Cell Cultures
J. Virol., February 1, 2006; 80(3): 1087 - 1097.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
D. J. White, R. G. Means, G. S. Birkhead, E. M. Bosler, L. J. Grady, N. Chatterjee, J. Woodall, B. Hjelle, P. E. Rollin, T. G. Ksiazek, et al.
Human and Rodent Hantavirus Infection in New York State: Public Health Significance of an Emerging Infectious Disease
Arch Intern Med, April 8, 1996; 156(7): 722 - 726.
[Abstract] [PDF]

Home page
 JAMAHome page
J. W. Tappero, A. S. Khan, R. W. Pinner, J. D. Wenger, J. M. Graber, L. R. Armstrong, R. C. Holman, T. G. Ksiazek, R. F. Khabbaz, Hantavirus Task Force, et al.
Utility of Emergency, Telephone-Based National Surveillance for Hantavirus Pulmonary Syndrome
JAMA, February 7, 1996; 275(5): 398 - 400.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by the American Society of Tropical Medicine and Hygiene.