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Am. J. Trop. Med. Hyg., 50(6), 1994, pp. 727-734
Copyright © 1994 by The American Society of Tropical Medicine and Hygiene

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Evaluation of a Recombinant Parasite Antigen for the Diagnosis of Lymphatic Filariasis

Senarath Dissanayake, Huijun Zheng, Gerusa Dreyer, Min Xu, Laxman Watawana, Guanghua Cheng, Shihai Wang, Paul Morin, Bijia Deng, Liliana Kurniawan, Albert Vincent AND Willy F. Piessens
Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts; Department of Filariasis, Guizhou Provincial Institute of Parasitic Diseases, Guiyang, The People's Republic of China; Department of Parasitology, Aggeu Magalhaes Research Centre (FIOCRUZ), Recife, Brazil; Faculty of Medicine, Peradeniya, Sri Lanka; Department of Parasitology, Shanghai Medical University, Shanghai, The People's Republic of China; National Institute of Health, Research and Development, Jakarta, Indonesia; Department of Medicine, University of South Florida, Tampa, Florida

We evaluated the usefulness of a recombinant parasite antigen (recSXP1) for the serologic diagnosis of lymphatic filariasis. A large proportion of sera from microfilaremic donors living in five different endemic countries (356 of 446 [80%]) contained IgG antibodies to recSXP1, as do sera from ~33% of amicrofilaremic patients with acute filarial disease and/or indirect evidence of active filarial infection. Exposure to filarial worms per se does not appear sufficient to elicit an anti-SXP1 antibody response. Thus, this serologic test identifies a large proportion of persons with active lymphatic filariasis among residents of endemic areas.






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Copyright © 1994 by the American Society of Tropical Medicine and Hygiene.