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Am. J. Trop. Med. Hyg., 50(4), 1994, pp. 452-459
Copyright © 1994 by The American Society of Tropical Medicine and Hygiene

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Description of Guanarito Virus (Arenaviridae: Arenavirus), the Etiologic Agent of Venezuelan Hemorrhagic Fever

Robert B. Tesh, Peter B. Jahrling, Rosalba Salas AND Robert E. Shope
Yale Arbovirus Research Unit, Yale University School of Medicine, New Haven, Connecticut; Disease Assessment Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland; National Institute of Hygiene, Ministry of Health and Social Assistance, Caracas, Venezuela

This paper characterizes Guanarito virus, the etiologic agent of Venezuelan hemorrhagic fever. Based on its morphology and antigenic properties, Guanarito virus appears to be a new member of the Tacaribe complex of the genus Arenavirus, family Arenaviridae. Complement fixation and indirect fluorescent antibody tests showed that Guanarito virus and its antiserum are broadly cross-reactive with other members of the Tacaribe complex, but it can be differentiated from other members of the complex by neutralization test. Guanarito virus causes mortality in suckling mice and adult guinea pigs, but not in adult mice. Inoculated rhesus monkeys developed viremia and became ill; however, they subsequently recovered and responded with production of antibody. To date, all isolates of Guanarito virus have come from sick persons or wild rodents living within a single geographic focus in the central plains of Venezuela.




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Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses
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Copyright © 1994 by the American Society of Tropical Medicine and Hygiene.