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Treatment of Oxyuriasis with Pyrrovinyquinium Chloride (Poquil)^1,2,3,

Of 123 persons with oxyuriasis 60 complied with the criterion of infection, i.e., three positive Scotch tape swabs were obtained. A total of 45 patients were treated with pyrrovinyquinium chloride (Poquil), 15 were not. A minimum of seven negative swabs was chosen as the criterion of cure. Three of the 15 controls became and remained negative on at least seven examinations, a spontaneous cure rate of 20 per cent. All 45 of the treated group became negative, a cure rate of 100 per cent. These results were obtained without advising the patients to use any special sanitary measures. In two instances, only one member of a multiple-infected family was treated and even then cure resulted. Reinfection became patent at the earliest on the 40th day after completion of medication. No untoward effects of clinical importance were encountered.

¹ The generic name has been changed to pyrvinium chloride.

² This study was aided by a grant from the Department of Clinical Investigation, Parke, Davis and Company.

³ Presented at the Annual Meeting of the American Society of Tropical Medicine and Hygiene, Boston, Mass., November 4, 1955.