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Influence of the Amino Nucleoside of Puromycin on the Course and Pathology of Trypanosome Infections in Rabbits and Mice

The amino nucleoside of Puromycin was tested for its trypanocidal activity against Trypanosoma congolense, T. equinum, T. gambiense, and T. rhodesiense infections in mice and T. gambiense in rabbits. Data reported show that the drug was somewhat effective against T. congolense only when a small inoculum was used but was highly effective against the other species especially T. gambiense. By treating mice following each of a series of relapses it was not possible to produce true resistance to the drug but it was possible, due to the prolonged course of the infection, to produce changes in the central nervous system of the mouse comparable to those produced by trypanosomiasis in man.

¹ National Microbiological Institute, Laboratory of Tropical Diseases.

² National Institutes of Arthritis and Metabolic Diseases, Laboratory of Pathology and Histochemistry.

³ With the technical assistance of Harvey D. James, Jr.