AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 49(6), 1993, pp. 812-818
Copyright © 1993 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kawai, S.
Right arrow Articles by Suzuki, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kawai, S.
Right arrow Articles by Suzuki, M.

Morphologic Effects of Artemether on Plasmodium falciparum in Aotus trivirgatus

Satoru Kawai, Shigeyuki Kano AND Mamoru Suzuki
Department of Parasitology, Gunma University School of Medicine, Maebashi, Japan

The effects of artemether on the morphology of Plasmodium falciparum were studied in an owl monkey (Aotus trivirgatus) when parasitemia reached 33% and the animal became severely ill. The earliest and the most distinctive ultrastructural changes following the administration of artemether were marked swelling of the mitochondria in the parasites, followed by the appearance of electron-dense chromatin materials in the nucleic and clumping of ribosomes. The initial change was observed within 2 hr of administration of the drug. These findings correlate well with the rapid and effective action of artemether, which has been demonstrated in human clinical trials.




This article has been cited by other articles:


Home page
 International Journal of ToxicologyHome page
L. H. Xie, T. O. Johnson, P. J. Weina, Y. Si, A. Haeberle, R. Upadhyay, E. Wong, and Q. Li
Risk Assessment and Therapeutic Indices of Artesunate and Artelinate in Plasmodium berghei-Infected and Uninfected Rats
International Journal of Toxicology, July 1, 2005; 24(4): 251 - 264.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
Q. L. Fivelman, I. S. Adagu, and D. C. Warhurst
Modified Fixed-Ratio Isobologram Method for Studying In Vitro Interactions between Atovaquone and Proguanil or Dihydroartemisinin against Drug-Resistant Strains of Plasmodium falciparum
Antimicrob. Agents Chemother., November 1, 2004; 48(11): 4097 - 4102.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by the American Society of Tropical Medicine and Hygiene.