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Am. J. Trop. Med. Hyg., 48(6), 1993, pp. 818-822
Copyright © 1993 by The American Society of Tropical Medicine and Hygiene

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Isolated Pontine Lesion in Algid Cerebral Malaria: Clinical Features, Management, and Magnetic Resonance Imaging Findings

Andreas W. Kampfl, Guenther G. Birbamer, Bettina E. Pfausler, Hans P. Haring AND Erich Schmutzhard
Department of Neurology, Intensive Care Unit, and Department of Magnetic Resonance Imaging and Spectroscopy, University Hospital, Innsbruck, Austria

Malaria, the most important of all tropical diseases, causes approximately one million deaths per year. In Plasmodium falciparum malaria, the organs most affected are the brain, kidneys, lungs, and liver. Cerebral involvement is the most important lethal complication with a mortality rate of up to 50%. We report a patient with malignant, tertian falciparum malaria with an initial parasitemia rate of 60% and severe cerebral, hepatorenal, and pulmonary involvement. In addition to the severe diffuse encephalopathy, an initial neurologic examination showed signs of a pontine lesion that was confirmed by cerebral magnetic resonance imaging. We therefore conclude that cerebral malaria may be responsible for focal neurologic lesions that can be demonstrated by this procedure.




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C J Das and R Sharma
Central pontine myelinolysis in a case of cerebral malaria
Br. J. Radiol., December 1, 2007; 80(960): e293 - e295.
[Abstract] [Full Text] [PDF]




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