HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Shmuklarsky, M. J. Articles by Schuster, B. G. Search for Related Content PubMed PubMed Citation Articles by Shmuklarsky, M. J. Articles by Schuster, B. G.

Comparison of ß-Artemether and ß-Arteether against Malaria Parasites In vitro and In vivo

The antimalarial activity of ß-artemether and ß-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites, in mice infected with P. berghei, and in Aotus monkeys infected with chloroquine-resistant P. falciparum. In vitro, the mean 50% inhibitory concentration (IC₅₀) for ß-artemether was 1.74 nM (range 1.34–1.81 nM), and this value for ß-arteether was 1.61 nM (range 1.57–1.92 nM). They were approximately 2.5-fold more potent than artemisinin, which had a mean IC₅₀ of 4.11 nM (range 3.36–4.60 nM). In the mouse model, the 50% curative doses (CD₅₀) of ß-artemether and ß-arteether had a mean value of 55 mg/kg (32–78 mg/kg). The 50% effective curative doses (ED₅₀) in the Aotus monkey were 7.1 mg/kg (95% confidence interval [CI] = 3.7–13.5) for ß-artemether and 11.8 mg/kg (95% CI = 6.5–21.3) for ß-arteether. Overall, the activities of the two drugs were comparable.