AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 48(2), 1993, pp. 149-153
Copyright © 1993 by The American Society of Tropical Medicine and Hygiene

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The Effects of Hemoglobin Genotype and Abo Blood Group on the Formation of Rosettes by Plasmodium falciparum-Infected Red Blood Cells

Rachanee Udomsangpetch, James Todd, Johan Carlson AND Brian M. Greenwood
Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand Medical Research Council Laboratories, Fajara, The Gambia; Department of Immunology, University of Stockholm, Stockholm, Sweden

The mechanisms by which the hemoglobin genotype AS protect against severe malaria are not fully understood. We have investigated the possibility that protection might be achieved through an inability of red blood cells (RBC) with the AS genotype to form rosettes with RBC infected by Plasmodium falciparum. No evidence was obtained to support this hypothesis because RBC with the AS genotype formed rosettes with wild isolates of P. falciparum as readily as RBC with the AA genotype. However, the previous finding that parasitized RBC form rosettes more readily with RBC belonging to group A or B than with RBC belonging to group O was confirmed even in fresh clinical isolates.




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Copyright © 1993 by the American Society of Tropical Medicine and Hygiene.