HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Basco, L. K. Articles by Bras, J. L. Search for Related Content PubMed PubMed Citation Articles by Basco, L. K. Articles by Bras, J. L.

In Vitro Activity of Monodesethylamodiaquine and Amopyroquine against African Isolates and Clones of Plasmodium falciparum

The in vitro activity of monodesethylamodiaquine and amopyroquine was evaluated against chloroquine-susceptible and chloroquine-resistant African clones of Plasmodium falciparum. The chloroquine-resistant clone (50% inhibitory concentration [IC₅₀] = 1,630 nM) was 26 and 3.7 times less susceptible to monodesethylamodiaquine and amopyroquine, respectively, than the chloroquine-susceptible clone (IC₅₀ = 36.5 nM). Cross-resistance patterns of chloroquine, monodesethylamodiaquine, and amopyroquine were determined against 62 African isolates of P. falciparum obtained from imported cases of malaria in France, using an isotopic semimicro drug susceptibility test. Chloroquine-resistant isolates (n = 38) were significantly less susceptible to both monodesethylamodiaquine (IC₅₀ = 74.8 nM) and amopyroquine (IC₅₀ = 18.9 nM), as compared with the 24 chloroquine-susceptible isolates (IC₅₀ = 28.2 nM and 16.1 nM, respectively). A significant positive correlation was found between chloroquine and monodesethylamodiaquine (r = 0.903) and between chloroquine and amopyroquine (r = 0.371), indicating in vitro crossresistance among these drugs. These in vitro results suggest that the clinical response to amodiaquine and amopyroquine needs to be closely monitored in Africa.

This article has been cited by other articles:

				S. NKHOMA, M. MOLYNEUX, and S. WARD IN VITRO ANTIMALARIAL SUSCEPTIBILITY PROFILE AND PRCRT/PFMDR-1 GENOTYPES OF PLASMODIUM FALCIPARUM FIELD ISOLATES FROM MALAWI Am J Trop Med Hyg, June 1, 2007; 76(6): 1107 - 1112. [Abstract] [Full Text] [PDF]

				L. K. BASCO and P. RINGWALD MOLECULAR EPIDEMIOLOGY OF MALARIA IN CAMEROON. XXIV. TRENDS OF IN VITRO ANTIMALARIAL DRUG RESPONSES IN YAOUNDE, CAMEROON Am J Trop Med Hyg, January 1, 2007; 76(1): 20 - 26. [Abstract] [Full Text] [PDF]

				B. Pradines, P. Hovette, T. Fusai, H. L. Atanda, E. Baret, P. Cheval, J. Mosnier, A. Callec, J. Cren, R. Amalvict, et al. Prevalence of In Vitro Resistance to Eleven Standard or New Antimalarial Drugs among Plasmodium falciparum Isolates from Pointe-Noire, Republic of the Congo. J. Clin. Microbiol., July 1, 2006; 44(7): 2404 - 2408. [Abstract] [Full Text] [PDF]

				C. T. HAPPI, G. O. GBOTOSHO, O. A. FOLARIN, O. M. BOLAJI, A. SOWUNMI, D. E. KYLE, W. MILHOUS, D. F. WIRTH, and A. M. J. ODUOLA ASSOCIATION BETWEEN MUTATIONS IN PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER AND P. FALCIPARUM MULTIDRUG RESISTANCE 1 GENES AND IN VIVO AMODIAQUINE RESISTANCE IN P. FALCIPARUM MALARIA-INFECTED CHILDREN IN NIGERIA. Am J Trop Med Hyg, July 1, 2006; 75(1): 155 - 161. [Abstract] [Full Text] [PDF]