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Am. J. Trop. Med. Hyg., 47(4), 1992, pp. 405-412
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene

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Purification of Native Dengue-2 Viral Proteins and the Ability of Purified Proteins to Protect Mice

Robert Feighny, Jeanne Burrous, Jack McCown, Charles Hoke AND Robert Putnak
Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, DC

Both the envelope structural protein and the non-structural NS1 protein have been purified from the flavivirus dengue-2 by high-pressure liquid chromatography. These purified proteins maintain their reactivity with monoclonal antibodies. When tested in mice, the envelope protein elicited neutralizing antibodies and partially protected the animals against a lethal viral challenge. The mice responded to the non-structural protein by producing antibodies; however, these antibodies were not neutralizing and the mice were not protected.






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Copyright © 1992 by the American Society of Tropical Medicine and Hygiene.