AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 47(3), 1992, pp. 378-382
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene

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*CHLOROQUINE
*ERYTHROMYCIN

Activity of Azithromycin (CP-62,993) and Erythromycin against Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium Falciparum in Vitro

Bruce A. Gingras AND James B. Jensen
Department of Microbiology, Michigan State University, East Lansing, Michigan

Several antibiotics, including the macrolide erythromycin and the azalides azithromycin (CP-62,993) and CP-63,956, that inhibit protein synthesis on 70S ribosomes demonstrated antimalarial effects in vitro against two strains of Plasmodium falciparum, one sensitive to chloroquine and the other resistant. In 48-hr incubations, erythromycin was 10-fold less potent than the azalides against the chloroquine-resistant strain. Erythromycin and the azalides were essentially equipotent against the chloroquine-sensitive strain. An additive effect occurred with the azalides in combination with chloroquine against both strains, but this was not seen with erythromycin.




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Copyright © 1992 by the American Society of Tropical Medicine and Hygiene.