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Am. J. Trop. Med. Hyg., 47(3), 1992, pp. 276-283
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene

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Efficacy of Bovine Milk Immunoglobulin Concentrate in Preventing Illness after Shigella Flexneri Challenge

Carol O. Tacket, Steven B. Binion, Eileen Bostwick, Genevieve Losonsky, Michael J. Roy AND Robert Edelman
Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland; GalaGen Inc., Minneapolis, Minnesota; U. S. Army Medical Materiel Development Activity, Fort Detrick, Maryland

The protective efficacy of oral bovine immunoglobulin concentrates derived from colostrum against challenge with Shigella flexneri was studied in healthy adult volunteers in a randomized, double-blind fashion. Volunteers were given a product consisting of hyperimmune immunoglobulin concentrate with a high titer of anti-S. flexneri 2a lipopolysaccharide (LPS) with sodium bicarbonate or a control preparation with sodium bicarbonate three times a day for seven days. On the third day of treatment, volunteers received a challenge of 103 colony-forming units of S. flexneri 2a strain 2457T. None of the volunteers who received the high-titered hyperimmune product became ill, compared with 45% of volunteers who received the placebo (P < 0.05). The duration of shedding of the challenge organism was decreased, and the active immune responses to S. flexneri LPS were less frequent and of lower magnitude in volunteers given the immunoglobulin concentrate than in those in the control group. High-titered, orally administered bovine immunoglobulin concentrate protects against shigellosis and may be useful in preventing shigellosis among travelers, military personnel, and individuals at risk during a Shigella outbreak.




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T Aebischer, D Bumann, H J Epple, W Metzger, T Schneider, G Cherepnev, A K Walduck, D Kunkel, V Moos, C Loddenkemper, et al.
Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines
Gut, August 1, 2008; 57(8): 1065 - 1072.
[Abstract] [Full Text] [PDF]


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Copyright © 1992 by the American Society of Tropical Medicine and Hygiene.