AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 46(6), 1992, pp. 649-653
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Herrera-Basto, E.
Right arrow Articles by Sepulveda-Amor, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Herrera-Basto, E.
Right arrow Articles by Sepulveda-Amor, J.

First Reported Outbreak of Classical Dengue Fever at 1,700 Meters above Sea Level in Guerrero State, Mexico, June 1988

Emilio Herrera-Basto, D. Rebecca Prevots, Ma. Luisa Zarate, J. Luis Silva AND Jaime Sepulveda-Amor
Directorate of Epidemiology, Ministry of Health, Mexico City, Mexico City, Mexico; Division of Immunization, Centers for Disease Control, Atlanta, Georgia; Department of Virology, National Epidemiologic and Reference Laboratory, Mexico City, Mexico; Jurisdiction of Iguala, Coordinated Health Services of the State of Guerrero, Mexico; Subsecretary of Health, Ministry of Health, Mexico City, Mexico

An outbreak of classical dengue fever occurred from March to August 1988 in the city of Taxco, Guerrero State, Mexico. Taxco is at an elevation of 1,700 meters above sea level, and this study represents the highest altitude at which an outbreak of dengue has been documented. An investigation was conducted to obtain serologic confirmation of dengue infection, determine the extent of the outbreak, and identify risk factors for dengue illness. Toxorhynchites cell lines were used for viral isolation, and hemagglutination inhibition was used to measure anti-dengue antibody titers. The case definition used in the investigation was any person with fever, headache, myalgias, and arthralgias, or rash or retroocular pain. Dengue virus type 1 was isolated from five acute cases. Of 1,686 persons living in the affected area, 42% (715) met the case definition. Large (200-liter) water containers were significantly associated with infection (relative risk = 1.7, 95% confidence interval 1.5–1.9). The effect of altitude on epidemic transmission is most likely modulated by seasonal temperatures. The epidemiologic and serologic confirmation of a dengue outbreak at 1,700 meters above sea level represents the capability of Aedes aegypti to adapt to new environments, and the potential for epidemic spread in cities at comparable altitudes or higher.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by the American Society of Tropical Medicine and Hygiene.