AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 46(5), 1992, pp. 520-523
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, L. X.
Right arrow Articles by Weller, P. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, L. X.
Right arrow Articles by Weller, P. F.

Release of Prostaglandin E2 by Microfilariae of Wuchereria bancrofti and Brugia malayi

Leo X. Liu, Janet E. Buhlmann AND Peter F. Weller
Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Infectious Diseases Division, Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts

To elucidate the local release of immunomodulatory prostaglandins by intravascular filarial parasites, the formation of prostaglandin E2 (PGE2) was examined in individual microfilariae of Wuchereria bancrofti and Brugia malayi. Following incubation of living microfilariae immobilized in an agar matrix, prostaglandins released by the parasites were fixed by carbodiimide and localized by indirect immunofluorescence. Prostaglandin E2 was specifically detected around the entire surface of microfilariae with anti-PGE2 antiserum, but not with control nonimmune or PGE2 affinity-immunoadsorbed antiserum. These results provide direct evidence that individual microfilariae of W. bancrofti as well as B. malayi release prostaglandins into their microenvironment. The release of PGE2 by these intravascular parasites may modulate host leukocyte responses, and thereby contribute to the immune defects observed in infected humans with peripheral microfilaremia.




This article has been cited by other articles:


Home page
 CVIHome page
R. Morchon, J. Lopez-Belmonte, A. Rodriguez-Barbero, and F. Simon
High Levels of Serum Thromboxane B2 Are Generated during Human Pulmonary Dirofilariosis
Clin. Vaccine Immunol., October 1, 2006; 13(10): 1175 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
M. C. Noverr, J. R. Erb-Downward, and G. B. Huffnagle
Production of Eicosanoids and Other Oxylipins by Pathogenic Eukaryotic Microbes
Clin. Microbiol. Rev., July 1, 2003; 16(3): 517 - 533.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by the American Society of Tropical Medicine and Hygiene.