HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Monath, T. P. Search for Related Content PubMed PubMed Citation Articles by Monath, T. P.

Yellow Fever: Victor, Victoria? Conqueror, Conquest? Epidemics and Research in the last Forty Years and Prospects for the Future^*

Yellow fever once ranked among the greatest of human afflictions, conquered attempts at colonial settlement and economic development, and caused epidemics with much suffering in towns and cities as far north as Boston and Swansea. The conquest of yellow fever began in 1900 with Walter Reed's decisive investigations that proved transmission of the virus by Aedes aegypti, expelled public fear and confusion about causation, and provided a practical recipe for combating the disease. By 1927, the yellow fever virus had been isolated. Within a decade, tests were generated for measuring human immunity, and the French neurotropic and 17D live, attenuated vaccines were developed. Although discovery of the jungle cycle of yellow fever transmission in 1935 dispelled hopes of ever eradicating the disease, widescale use of vaccines in the 1940s and systematic efforts to subdue Ae. aegypti brought yellow fever under control.

^* Presented at the Charles Franklin Craig Lecture at the 39th Annual Meeting of the American Society of Tropical Medicine and Hygiene, New Orleans, LA, November 1990.

This article has been cited by other articles:

				E. Norrby Yellow fever and Max Theiler: the only Nobel Prize for a virus vaccine J. Exp. Med., November 26, 2007; 204(12): 2779 - 2784. [Abstract] [Full Text] [PDF]