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Comparison of Antimalarial Efficacy of , ß, and /ß Arteether against Plasmodium cynomolgi B Infection in Monkeys

The blood schizontocidal activity of and ß arteether has been compared with that of /ß arteether (a 30:70 mixture of and ß isomers), which is a fast-acting blood schizontocide undergoing phase I clinical trials at the Central Drug Research Institute. Both ß and /ß arteether have comparable activity and are curative at a dose of 5 mg/kg for 3 days against blood-induced Plasmodium cynomolgi B infection in the rhesus monkey; arteether alone is slightly less active, with a 50% cure rate at the above dose.

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				A. PAREEK, A. NANDY, D. KOCHAR, K. H. PATEL, S. K. MISHRA, and P. C. MATHUR EFFICACY AND SAFETY OF {beta}-ARTEETHER AND {alpha}/{beta}-ARTEETHER FOR TREATMENT OF ACUTE PLASMODIUM FALCIPARUM MALARIA. Am J Trop Med Hyg, July 1, 2006; 75(1): 139 - 142. [Abstract] [Full Text] [PDF]