HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Churdboonchart, V. Articles by Sirinavin, S. Search for Related Content PubMed PubMed Citation Articles by Churdboonchart, V. Articles by Sirinavin, S.

Antibodies against Dengue Viral Proteins in Primary and Secondary Dengue Hemorrhagic Fever

Antibodies against dengue viral proteins were demonstrated in sera from dengue-infected patients by polyacrylamide gel electrophoresis, Western blotting, and enzyme immunoassay. Primary dengue cases showed low titers of IgG class antibodies to envelope (E) proteins and two non-structural proteins, NS3 and NS5, in sera collected during the convalescent phase. Secondary dengue- infected patients always demonstrated IgG antibodies to E proteins in sera collected during the acute phase, and high titers of IgG antibodies to many other proteins, including NS1, NS3, NS5, and C proteins in sera collected during the convalescent phase. Appearance of antibodies to E, NS3, and NS5 could be detected within five days after the onset of fever. These three dengue viral proteins and their corresponding antibodies may be involved in the immunopathologic mechanism underlying this disease. For diagnostic purposes, identifying the non-structural proteins such as NS3 and NS5 may be the best means for early confirmation of the disease.

This article has been cited by other articles:

				B. Etemad, G. Batra, R. Raut, S. Dahiya, S. Khanam, S. Swaminathan, and N. Khanna An Envelope Domain III-based Chimeric Antigen Produced in Pichia pastoris Elicits Neutralizing Antibodies Against All Four Dengue Virus Serotypes Am J Trop Med Hyg, September 1, 2008; 79(3): 353 - 363. [Abstract] [Full Text] [PDF]

				C.-Y. Lai, W.-Y. Tsai, S.-R. Lin, C.-L. Kao, H.-P. Hu, C.-C. King, H.-C. Wu, G.-J. Chang, and W.-K. Wang Antibodies to Envelope Glycoprotein of Dengue Virus during the Natural Course of Infection Are Predominantly Cross-Reactive and Recognize Epitopes Containing Highly Conserved Residues at the Fusion Loop of Domain II J. Virol., July 1, 2008; 82(13): 6631 - 6643. [Abstract] [Full Text] [PDF]

				L. Bernardo, A. Izquierdo, I. Prado, D. Rosario, M. Alvarez, E. Santana, J. Castro, R. Martinez, R. Rodriguez, L. Morier, et al. Primary and Secondary Infections of Macaca fascicularis Monkeys with Asian and American Genotypes of Dengue Virus 2 Clin. Vaccine Immunol., March 1, 2008; 15(3): 439 - 446. [Abstract] [Full Text] [PDF]

				A. K. I. Falconar Antibody Responses Are Generated to Immunodominant ELK/KLE-Type Motifs on the Nonstructural-1 Glycoprotein during Live Dengue Virus Infections in Mice and Humans: Implications for Diagnosis, Pathogenesis, and Vaccine Design Clin. Vaccine Immunol., May 1, 2007; 14(5): 493 - 504. [Abstract] [Full Text] [PDF]

				T. Oliphant, G. E. Nybakken, M. Engle, Q. Xu, C. A. Nelson, S. Sukupolvi-Petty, A. Marri, B.-E. Lachmi, U. Olshevsky, D. H. Fremont, et al. Antibody Recognition and Neutralization Determinants on Domains I and II of West Nile Virus Envelope Protein J. Virol., December 15, 2006; 80(24): 12149 - 12159. [Abstract] [Full Text] [PDF]