HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Collins, W. E. Articles by Procell, P. M. Search for Related Content PubMed PubMed Citation Articles by Collins, W. E. Articles by Procell, P. M.

Immunization of Owl Monkeys with the Ring-Infected Erythrocyte Surface Antigen of Plasmodium falciparum

Aotus nancymai were immunized with the 4-mer, 8-mer, and 11-mer repeat peptides of the ring-infected erythrocyte surface antigen molecule of Plasmodium falciparum conjugated to diphtheria toxoid with muramyl dipeptide (MDP) as adjuvant. Immunization failed to induce protective immunity against the Uganda Palo Alto strain of P. falciparum as judged by maximum levels of parasitemia of immunized monkeys relative to those of controls. The fused polypeptide FPAg632, when combined with MDP, also failed to induce protective immunity. However, the maximum level of parasitemia and serologic response to the 11-mer peptide were inversely correlated. The safety of the use of MDP was evident.

This article has been cited by other articles:

				A. Martinelli, S. Cheesman, P. Hunt, R. Culleton, A. Raza, M. Mackinnon, and R. Carter A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites PNAS, January 18, 2005; 102(3): 814 - 819. [Abstract] [Full Text] [PDF]