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Am. J. Trop. Med. Hyg., 43(6), 1990, pp. 571-575
Copyright © 1990 by The American Society of Tropical Medicine and Hygiene

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Gametocytocidal Activity of the Antimalarial {alpha}/ß Arteether against Plasmodium cynomolgi B

Renu Tripathi, G. P. Dutta AND R. A. Vishwakarma
Central Drug Research Institute, Lucknow, India; Central Institute of Medicinal and Aromatic Plants, Lucknow, India

A new sesquiterpene lactone {alpha}/ß arteether (a 30:70 mixture of enantiomers), which possesses very high blood schizontocidal activity, has been evaluated for gametocytocidal/sporontocidal action against Plasmodium cynomolgi B infection in the rhesus monkey. This paper reports gametocytocidal action of this new antimalarial drug at 2.5–5 mg/kg (single im dose) against P. cynomolgi B as shown by the complete absence of mosquito infectivity. No sporontocidal action was demonstrable in the vector at a dose of up to 20–50 mg/kg im.






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Copyright © 1990 by the American Society of Tropical Medicine and Hygiene.