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Infection of Chimpanzees with the Uganda I/CDC Strain of Plasmodium malariae

Nine splenectomized chimpanzees were infected with the Uganda I/CDC strain of Plasmodium malariae. Two had no history of previous malarial infection, whereas 6 had been infected with P. vivax and 1 with P. vivax and P. ovale. The animals with no previous infection had maximum parasitemias of 8,740 and 10,800/mm³. The other animals had maximum parasite counts of 930–75,700/mm³. Anopheles freeborni, An. stephensi, An. dirus, An. maculatus, An. quadrimaculatus, An. culicifacies, An. arabiensis, and An. gambiae were readily infected by feeding through membranes on heparinized blood from these animals.

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				W. E. Collins and G. M. Jeffery Plasmodium malariae: Parasite and Disease Clin. Microbiol. Rev., October 1, 2007; 20(4): 579 - 592. [Abstract] [Full Text] [PDF]