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Norfloxacin for the Prophylaxis of Travelers' Diarrhea in U.S. Military Personnel

Norfloxacin, an oral fluoroquinolone (dose 400 mg daily), was compared to a placebo in a double blinded randomized trial for the prophylaxis of travelers' diarrhea. The study was of U.S. Navy and Marine Corps personnel on shore leave in Alexandria, Egypt. A total of 222 subjects were available (105 norfloxacin, 117 placebo). In the placebo group, 26% (30/117) developed acute diarrhea vs. 2% (2/105) in the norfloxacin group. There were no significant side effects in either group.

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				M. S. RIDDLE, J. W. SANDERS, S. D. PUTNAM, and D. R. TRIBBLE Incidence, etiology, and impact of diarrhea among long-term travelers (us military and similar populations): a systematic review. Am J Trop Med Hyg, May 1, 2006; 74(5): 891 - 900. [Abstract] [Full Text] [PDF]