AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 41(6), 1989, pp. 657-663
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene

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Heightened Anti-Filarial Immune Responsiveness in a Haitian Pediatric Population

Wendy L. Hitch, Patrick J. Lammie AND Mark L. Eberhard
Tulane University, New Orleans, Louisiana; Louisiana State University Medical Center, New Orleans, Louisiana; and Centers for Disease Control, Atlanta, Georgia

The immunological consequences of exposure to filarial infection were examined by cross-sectional serological studies. Serum samples from 121 pediatric patients (18 months-15 years of age) were analyzed in parallel with a panel of sera from adults residing in the same area of Haiti. Parasite antigen specific IgG and IgE levels were determined by ELISA. IgG levels in children were significantly elevated in humoral immunoreactivity to Brugia pahangi extracts compared to adults. In addition, anti-filarial IgG levels in amicrofilaremic children were significantly greater than in microfilaremic children. In contrast, IgG levels in adults were equivalent independent of microfilaremic status. Anti-filarial IgE levels in sera from both children and adults were low in comparison to that of a subject with tropical pulmonary eosinophilia and were unrelated to clinical status. No correlations were found between humoral responses and age, sex, or degree of parasitemia. Sera from amicrofilaremic children and, to a lesser extent, adults recognize more antigens, particularly those of high molecular weight (>55 kDa), than sera from microfilaremic patients.




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W. G. Jaoko, E. Michael, D. W. Meyrowitsch, B. B. A. Estambale, M. N. Malecela, and P. E. Simonsen
Immunoepidemiology of Wuchereria bancrofti Infection: Parasite Transmission Intensity, Filaria-Specific Antibodies, and Host Immunity in Two East African Communities
Infect. Immun., December 1, 2007; 75(12): 5651 - 5662.
[Abstract] [Full Text] [PDF]


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Copyright © 1989 by the American Society of Tropical Medicine and Hygiene.