HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kaufman, B. M. Articles by Eckels, K. H. Search for Related Content PubMed PubMed Citation Articles by Kaufman, B. M. Articles by Eckels, K. H.

Monoclonal Antibodies for Dengue Virus prM Glycoprotein Protect Mice against Lethal Dengue Infection

Five murine monoclonal antibodies (Mabs) reactive against the prM glycoproteins of DEN-3 and -4 were used to passively protect mice in vivo against lethal challenge with homologous and heterologous dengue virus serotypes. Four of the 5 prM-reactive monoclonals cross-protected mice against heterologous challenge, whereas 1 protected against challenge with only the homologous serotype. Although in vitro binding to virions was readily demonstrated, only 2 of the prM Mabs had detectable neutralizing activity. The neutralizing activity could not be enhanced by anti-mouse immunoglobulin or complement. However, 4 of the 5 prM Mabs fixed complement. This is the first report of prM-specific Mabs that are protective in mice.

This article has been cited by other articles:

				J.-M. Kim, S.-I. Yun, B.-H. Song, Y.-S. Hahn, C.-H. Lee, H.-W. Oh, and Y.-M. Lee A Single N-Linked Glycosylation Site in the Japanese Encephalitis Virus prM Protein Is Critical for Cell Type-Specific prM Protein Biogenesis, Virus Particle Release, and Pathogenicity in Mice J. Virol., August 15, 2008; 82(16): 7846 - 7862. [Abstract] [Full Text] [PDF]

				A. Yamanaka, S. Kosugi, and E. Konishi Infection-Enhancing and -Neutralizing Activities of Mouse Monoclonal Antibodies against Dengue Type 2 and 4 Viruses Are Controlled by Complement Levels J. Virol., January 15, 2008; 82(2): 927 - 937. [Abstract] [Full Text] [PDF]

				T. Oliphant, G. E. Nybakken, M. Engle, Q. Xu, C. A. Nelson, S. Sukupolvi-Petty, A. Marri, B.-E. Lachmi, U. Olshevsky, D. H. Fremont, et al. Antibody Recognition and Neutralization Determinants on Domains I and II of West Nile Virus Envelope Protein J. Virol., December 15, 2006; 80(24): 12149 - 12159. [Abstract] [Full Text] [PDF]

				K. Clyde, J. L. Kyle, and E. Harris Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and Pathogenesis J. Virol., December 1, 2006; 80(23): 11418 - 11431. [Full Text] [PDF]

				A. K. I. Falconar, E. de Plata, and C. M. E. Romero-Vivas Altered Enzyme-Linked Immunosorbent Assay Immunoglobulin M (IgM)/IgG Optical Density Ratios Can Correctly Classify All Primary or Secondary Dengue Virus Infections 1 Day after the Onset of Symptoms, when All of the Viruses Can Be Isolated. Clin. Vaccine Immunol., September 1, 2006; 13(9): 1044 - 1051. [Abstract] [Full Text] [PDF]

				M. S. Diamond, E. M. Sitati, L. D. Friend, S. Higgs, B. Shrestha, and M. Engle A Critical Role for Induced IgM in the Protection against West Nile Virus Infection J. Exp. Med., December 15, 2003; 198(12): 1853 - 1862. [Abstract] [Full Text] [PDF]